ChemicalBook > CAS DataBase List > ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate

((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate

Product Name
((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate
CAS No.
864070-37-1
Chemical Name
((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate
Synonyms
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;Empagliflozin-4;Dapagliflozin-009;Jardiance Impurity H;Daglitele Impurity 6;Epaliflozin Ipurity 5;Empagliflozin impurity H;Dapagliflozin Impurity L;Empagliflozin Impurity 5;O-Desethyl Dapagliflozin (>80%)
CBNumber
CB92728624
Molecular Formula
C19H21ClO6
Formula Weight
380.82
MOL File
864070-37-1.mol
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((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Property

Boiling point:
628.3±55.0 °C(Predicted)
Density 
1.459±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
10.17±0.15(Predicted)
color 
White to off-white
Stability:
Hygroscopic
InChI
InChI=1/C19H21ClO6/c20-14-6-3-11(8-12(14)7-10-1-4-13(22)5-2-10)19-18(25)17(24)16(23)15(9-21)26-19/h1-6,8,15-19,21-25H,7,9H2/t15-,16-,17+,18-,19+/s3
InChIKey
ODQAIMBPQWETBE-YBDYQYBPNA-N
SMILES
O[C@@H]1[C@H]([C@H](O)[C@@H](CO)O[C@H]1C1C=CC(Cl)=C(CC2C=CC(O)=CC=2)C=1)O |&1:1,2,3,5,9,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H372Causes damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D290543
Product name
O-DesethylDapagliflozin
Packaging
5mg
Price
$135
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0010007
Product name
(2S,3R,4R,5S,6R)-2-(4-CHLORO-3-(4-HYDROXYBENZYL)PHENYL)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL
Purity
95.00%
Packaging
5MG
Price
$500.83
Updated
2021/12/16
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((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Chemical Properties,Usage,Production

Uses

O-Desethyl Dapagliflozin is derivative of antidiabetic drug Dapagliflozin (D185370), which is sodium-glucose transporter 2 inhibitor.

IC 50

SGLT2: 33 nM (IC50)

((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate Suppliers

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View Lastest Price from ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Dapagliflozin Impurity 3 864070-37-1
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-20
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Dapagliflozin Impurity 3 864070-37-1
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-02-13
Guangzhou PI PI BIOTECH INC
Product
Dapagliflozin Impurity 22 864070-37-1
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2022-04-21

864070-37-1, ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetateRelated Search:

(2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol Empagliflozin Impurity 35 Empagliflozin 2-Chloro-4'-fluorobenzophenone (R)-4-CHLORO-1,3-BUTANEDIOL (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Empagliflozin Impurity 23 N/A Dapagliflozin Impurity 20 EMpagliflozin iMpurity 14 Butanoic acid, 4-chloro-3-hydroxy-, (3S)- (3R,4S,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol Empagliflozin (R)-Isomer Dapagliflozin Impurity 19 D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1R)- Acetoxy Empagliflozin (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxyMethyl)-2-Methoxytetrahydro-2H-pyran-3,4,5-triol GLP-1

  • Dapagliflozin Impurity L
  • Empagliflozin-4
  • Dapagliflozin impurity 12/ O-Desethyl Dapagliflozin/(3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Daglitele Impurity 6
  • (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Empagliflozin impurity H
  • D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-, (1S)-
  • Jardiance Impurity H
  • (3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Dapagliflozin O-Desethyl Impurity
  • Empagliflozin Destetrahydrofuran Impurity
  • Empagliflozin Destetrahydrofuran ImpurityQ: What is Empagliflozin Destetrahydrofuran Impurity Q: What is the CAS Number of Empagliflozin Destetrahydrofuran Impurity Q: What is the storage condition of Empagliflozin Destetrahydrofuran Impurity Q: What are the applications of Empagliflozin Destetrahydrofuran Impurity
  • (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
  • Dapagliflozin-009
  • Epaliflozin Ipurity 5
  • 1-Chloro-4-(beta-D-glucopyranos-1-yl)-2-(4-hydroxybenzyl)-benzene
  • (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-D-glucitol
  • Empagliflozin Impurity 5
  • ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate
  • (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (Empagliflozin Impurity)
  • O-Desethyl Dapagliflozin, 10 mM in DMSO
  • Empagliflozin Impurity 5(Dapagliflozin Impurity 82)
  • O-Desethyl Dapagliflozin (>80%)
  • 864070-37-1