ASP-9521

Product Name: ASP-9521
CAS No.: 1126084-37-4
Chemical Name: ASP-9521
Synonyms: ASP-9521;ASP-9521, >98%;17HSD5 inhibitor;AKR1C3 inhibitor;ASP 9521. AKR1C3 inhibitor;Inhibitor,inhibit,ASP-9521,ASP 9521;ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR;ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR;1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol;[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
CBNumber: CB92731017
Molecular Formula: C19H26N2O3
Formula Weight: 330.42
MOL File: 1126084-37-4.mol

More

Less

ASP-9521 Property

Boiling point:: 543.9±30.0 °C(Predicted)
Density: 1.183±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM)
Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM)
form: A crystalline solid
pka: 15.23±0.29(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 27308
Product name: ASP9521
Packaging: 10mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 27308
Product name: ASP9521
Packaging: 25mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 27308
Product name: ASP9521
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Tocris

Product number: 6084
Product name: ASP9521
Purity: ≥98%(HPLC)
Packaging: 10
Price: $68
Updated: 2021/12/16

Tocris

Product number: 6084
Product name: ASP9521
Purity: ≥98%(HPLC)
Packaging: 50
Price: $284
Updated: 2021/12/16

More

Less

ASP-9521 Chemical Properties,Usage,Production

Description

ASP9521 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17β-HSD5/AKR1C3; IC₅₀ = 120 nM). It is selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC₅₀ = 20 μM). ASP9521 inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC₅₀s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively). It inhibits androstenedione-dependent production of prostate specific androgen (PSA) in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3. ASP9521 (3 and 10 mg/kg) inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model.

Uses

ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). AKR1C3 is a promising therapeutic target in castration-resistant prostate cancer

ASP-9521 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ASP-9521 Suppliers

China 42 India 1 United Kingdom 1 United States 10 Global 54

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8012
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9747
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Country: China
ProdList: 1988
Advantage: 58

More

Less

View Lastest Price from ASP-9521 manufacturers

Career Henan Chemica Co

Product: ASP-9521 1126084-37-4
Price: US $1.00/g
Min. Order: 1g
Purity: Min98% HPLC/GC
Supply Ability: g/kg/ton Coreychem-Nicole
Release date: 2020-11-06

1126084-37-4, ASP-9521Related Search:

6-Methoxyindole 3,4,5-Trimethoxybenzoyl chloride

ASP-9521

1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol

AKR1C3 inhibitor

ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR

[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone

17HSD5 inhibitor

ASP 9521. AKR1C3 inhibitor

ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR

ASP-9521, >98%

Methanone, [4-(2-hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)-

(4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl)(5-methoxy-1H-indol-2-yl)methanone

Inhibitor,inhibit,ASP-9521,ASP 9521

1126084-37-4