ASP-9521
- Product Name
- ASP-9521
- CAS No.
- 1126084-37-4
- Chemical Name
- ASP-9521
- Synonyms
- ASP-9521;ASP-9521, >98%;17HSD5 inhibitor;AKR1C3 inhibitor;ASP 9521. AKR1C3 inhibitor;Inhibitor,inhibit,ASP-9521,ASP 9521;ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR;ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR;1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol;[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
- CBNumber
- CB92731017
- Molecular Formula
- C19H26N2O3
- Formula Weight
- 330.42
- MOL File
- 1126084-37-4.mol
ASP-9521 Property
- Boiling point:
- 543.9±30.0 °C(Predicted)
- Density
- 1.183±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM)
Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM) - form
- A crystalline solid
- pka
- 15.23±0.29(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 27308
- Product name
- ASP9521
- Packaging
- 10mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 27308
- Product name
- ASP9521
- Packaging
- 25mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 27308
- Product name
- ASP9521
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 6084
- Product name
- ASP9521
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 6084
- Product name
- ASP9521
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $284
- Updated
- 2021/12/16
ASP-9521 Chemical Properties,Usage,Production
Description
ASP9521 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17β-HSD5/AKR1C3; IC50 = 120 nM). It is selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC50 = 20 μM). ASP9521 inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC50s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively). It inhibits androstenedione-dependent production of prostate specific androgen (PSA) in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3. ASP9521 (3 and 10 mg/kg) inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model.
Uses
ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). AKR1C3 is a promising therapeutic target in castration-resistant prostate cancer
ASP-9521 Preparation Products And Raw materials
Raw materials
Preparation Products
ASP-9521 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from ASP-9521 manufacturers
- Product
- ASP-9521 1126084-37-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- Min98% HPLC/GC
- Supply Ability
- g/kg/ton Coreychem-Nicole
- Release date
- 2020-11-06