ASP-9521

Product Name: ASP-9521
CAS No.: 1126084-37-4
Chemical Name: ASP-9521
Synonyms: ASP-9521;ASP-9521, >98%;17HSD5 inhibitor;AKR1C3 inhibitor;ASP 9521. AKR1C3 inhibitor;Inhibitor,inhibit,ASP-9521,ASP 9521;ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR;ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR;1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol;[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
CBNumber: CB92731017
Molecular Formula: C19H26N2O3
Formula Weight: 330.42
MOL File: 1126084-37-4.mol

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ASP-9521 Property

Boiling point:: 543.9±30.0 °C(Predicted)
Density: 1.183±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM)
Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM)
form: A crystalline solid
pka: 15.23±0.29(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27308
Product name: ASP9521
Packaging: 10mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 27308
Product name: ASP9521
Packaging: 25mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 27308
Product name: ASP9521
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Tocris

Product number: 6084
Product name: ASP9521
Purity: ≥98%(HPLC)
Packaging: 10
Price: $68
Updated: 2021/12/16

Tocris

Product number: 6084
Product name: ASP9521
Purity: ≥98%(HPLC)
Packaging: 50
Price: $284
Updated: 2021/12/16

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ASP-9521 Chemical Properties,Usage,Production

Description

ASP9521 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17β-HSD5/AKR1C3; IC₅₀ = 120 nM). It is selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC₅₀ = 20 μM). ASP9521 inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC₅₀s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively). It inhibits androstenedione-dependent production of prostate specific androgen (PSA) in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3. ASP9521 (3 and 10 mg/kg) inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model.

Uses

ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). AKR1C3 is a promising therapeutic target in castration-resistant prostate cancer

ASP-9521 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASP-9521 Suppliers

China 48 India 1 United Kingdom 1 United States 10 Global 60

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

United States Biological

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Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Axon Medchem LLC

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Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

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View Lastest Price from ASP-9521 manufacturers

Career Henan Chemica Co

Product: ASP-9521 1126084-37-4
Price: US $1.00/g
Min. Order: 1g
Purity: Min98% HPLC/GC
Supply Ability: g/kg/ton Coreychem-Nicole
Release date: 2020-11-06

1126084-37-4, ASP-9521Related Search:

6-Methoxyindole 3,4,5-Trimethoxybenzoyl chloride

ASP-9521

1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol

AKR1C3 inhibitor

ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR

[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone

17HSD5 inhibitor

ASP 9521. AKR1C3 inhibitor

ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR

ASP-9521, >98%

Methanone, [4-(2-hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)-

(4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl)(5-methoxy-1H-indol-2-yl)methanone

Inhibitor,inhibit,ASP-9521,ASP 9521

1126084-37-4