Methyl 4-chloro-6-Methoxypicolinate
- Product Name
- Methyl 4-chloro-6-Methoxypicolinate
- CAS No.
- 204378-37-0
- Chemical Name
- Methyl 4-chloro-6-Methoxypicolinate
- Synonyms
- Regorafenib Impurity 125;Levocarnitine Impurity 49;Methyl 4-chloro-6-Methoxypicolinate;2-Pyridinecarboxylic acid, 4-chloro-6-methoxy-, methyl ester
- CBNumber
- CB92732933
- Molecular Formula
- C8H8ClNO3
- Formula Weight
- 201.61
- MOL File
- 204378-37-0.mol
Methyl 4-chloro-6-Methoxypicolinate Property
- Boiling point:
- 290.8±35.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.53±0.10(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- M342768
- Product name
- Methyl4-chloro-6-methoxypicolinate
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 0973DU
- Product name
- Methyl4-chloro-6-methoxypicolinate
- Packaging
- 250mg
- Price
- $599
- Updated
- 2021/12/16
- Product number
- 153540
- Product name
- Methyl 4-chloro-6-methoxypicolinate
- Purity
- 95%
- Packaging
- 1g
- Price
- $5550
- Updated
- 2021/12/16
- Product number
- A206198
- Product name
- Methyl4-chloro-6-methoxypicolinate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 204378370
- Product name
- Methyl4-chloro-6-methoxypyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $680
- Updated
- 2021/12/16
Methyl 4-chloro-6-Methoxypicolinate Chemical Properties,Usage,Production
Synthesis
1443759-42-9
204378-37-0
General procedure for the synthesis of methyl 4-chloro-6-methoxypyridine-2-carboxylate from methyl 4-amino-6-methoxy-pyridine-2-carboxylate: to a mixture of 1.25 mL (10.5 mmol) of tert-butyl nitrite and 1.42 g (10.5 mmol) of copper(II) chloride in 40 mL of acetonitrile was added slowly, dropwise, at 40 °C, 1.20 g (6.59 mmol) of 4- methyl amino-6-methoxy-pyridine-2-carboxylate dissolved in 10 mL of acetonitrile. The reaction mixture was stirred at 80 °C for 1 h and then poured into ice water, acidified with 4 M aqueous HCl and extracted with EtOAc. The combined organic phases were dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by fast chromatography (eluent ratio: petroleum ether/EtOAc 3/1→2/1). A product of 650 mg was obtained in 49% yield. eSI-MS: m/z = 202 (M + H)+. hPLC retention time: 1.12 min (Method 5).
References
[1] Patent: WO2013/87805, 2013, A1. Location in patent: Page/Page column 75
[2] Patent: US2013/158042, 2013, A1. Location in patent: Paragraph 0477; 0478; 0479; 0480; 0481
Methyl 4-chloro-6-Methoxypicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
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