(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate

Product Name: (1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate
CAS No.: 1187479-72-6
Chemical Name: (1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate
Synonyms: Bortezomib Impurity 53;(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate;tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)-benzoyl)piperazin-1-carboxylate;Carbamic acid, N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
CBNumber: CB92735156
Molecular Formula: C29H45BN2O5
Formula Weight: 512.49
MOL File: 1187479-72-6.mol

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(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Property

Boiling point:: 635.7±55.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
pka: 11.39±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H294360
Product name: N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-CarbamicAcid1,1-DimethylethylEster
Packaging: 25mg
Price: $195
Updated: 2021/12/16

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(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Chemical Properties,Usage,Production

Uses

N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-Carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of bortezomib (B675700).Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer.

(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate Suppliers

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1187479-72-6, (1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronateRelated Search:

Isovaleraldehyde Bortezomib Impurity 8 4,6-Methano-1,3,2-benzodioxaborole,2-[(1S)-1-chloro-3-Methylbutyl]hexahydro-3a,5,5-triMethyl-,(3aS,4S,6S,7aR)- Bortezomib Impurity 57 (R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanoic acid BORTEZOMIB-PINANEDIOL Bortezomib intermediates II 3,6-Dibenzylhexahydropyrazine-2,5-dione Bortezomib Impurity 52 Bortezomib Impurity 9 Desisobutyl-n-butyl BortezoMib (IS,2S,3R,5S)-Pinanediol-L-phenylalanine-L-leucine boronate, HCl salt (S,E)-N-(1-((3-methylbut-1-en-1-yl)amino)-1-oxo-3-phenylpropan-2-yl) pyrazine-2-carboxamide Bortezomib Impurity 32 (S)-(+)-PINANEDIOL (DICHLORMETHYL)BORONATE Bortezomib Impurity 47 HCl Bortezomib Impurity 60 4,6-Methano-1,3,2-benzodioxaborole-2-methanamine

(1S,2S,3R,5S)-PinanediolN-BOC-L-phenylalanine-L-leucine boronate

tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)-benzoyl)piperazin-1-carboxylate

Bortezomib Impurity 53

Carbamic acid, N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester

1187479-72-6