MHY1485

ChemicalBook > CAS DataBase List > MHY1485

Product Name: MHY1485
CAS No.: 326914-06-1
Chemical Name: MHY1485
Synonyms: MHY1485;MHY1485 USP/EP/BP;MHY-1485;MHY 1485;4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine;4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4,6-di-4-morpholinyl-N-(4-nitrophenyl)-;4,6-Bis(morpholin-4-yl)-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
CBNumber: CB92737150
Molecular Formula: C17H21N7O4
Formula Weight: 387.39
MOL File: 326914-06-1.mol

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MHY1485 Property

Melting point:: 256-259 °C
Boiling point:: 643.3±65.0 °C(Predicted)
Density: 1.415±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble2mg/mL, clear (warmed)
form: powder
pka: 6.19±0.10(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3
HS Code: 2934.99.3900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0810
Product name: MHY 1485
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $73.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0810
Product name: MHY 1485
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $298
Updated: 2024/03/01

TCI Chemical

Product number: M3107
Product name: MHY 1485
Purity: >95.0%(HPLC)
Packaging: 25mg
Price: $203
Updated: 2024/03/01

TCI Chemical

Product number: M3107
Product name: MHY 1485
Purity: >95.0%(HPLC)
Packaging: 100mg
Price: $557
Updated: 2024/03/01

Cayman Chemical

Product number: 18008
Product name: MHY 1485
Purity: ≥95%
Packaging: 5mg
Price: $56
Updated: 2024/03/01

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MHY1485 Chemical Properties,Usage,Production

Description

MHY1485 is a cell-permeable activator of mTOR that has been shown to increase levels of cellular mTOR Ser²⁴⁴⁸ and downstream substrate 4E-BP Thr^37/46 phosphorylation in rat liver Ac2F cells. It can induce cellular LC3-II accumulation in Ac2F cells and has been shown to inhibit autophagy by suppressing the fusion between autophagosomes and lysosomes.

Uses

MHY1485 has been used:

to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation
to inhibit autophagy
as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Biochem/physiol Actions

MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.

References

1) Choy et al. (2012), Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion; PLoS One, 7(8) e43418 2) Cheng et al. (2015), Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators; PLoS One, 10(2) e0117769 3) Zhao et al. (2016), MHY1485 activates mTOR and protects osteoblasts from dexamethasone; Biochem. Biophys. Res. Commun., 481 212 4) Yang et al. (2017), MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling; Oncotarget, 8 12775 5) Li and Siragy (2015), (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose; J. Physiol. Endocrinol. Metab., 309 E302

MHY1485 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MHY1485 manufacturers

Career Henan Chemical Co

Product: 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine 326914-06-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

326914-06-1, MHY1485Related Search:

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE MIF Antagonist, ISO-1 Chloroquine diphosphate Thapsigargin

MHY1485

4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

MHY-1485;MHY 1485

1,3,5-Triazin-2-amine, 4,6-di-4-morpholinyl-N-(4-nitrophenyl)-

4,6-Bis(morpholin-4-yl)-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

MHY1485 USP/EP/BP

326914-06-1

C17H21N7O4

Inhibitors