ChemicalBook > CAS DataBase List > MHY1485

MHY1485

Product Name: MHY1485
CAS No.: 326914-06-1
Chemical Name: MHY1485
Synonyms: MHY1485;MHY1485 ，S7811;MHY-1485;MHY 1485;MHY1485 USP/EP/BP;MHY1485, 10 mM in DMSO;mTOR Activator, MHY1485;4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine;4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4,6-di-4-morpholinyl-N-(4-nitrophenyl)-;4,6-Bis(morpholin-4-yl)-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
CBNumber: CB92737150
Molecular Formula: C17H21N7O4
Formula Weight: 387.39
MOL File: 326914-06-1.mol

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MHY1485 Property

Melting point:: 256-259 °C
Boiling point:: 643.3±65.0 °C(Predicted)
Density: 1.415±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble2mg/mL, clear (warmed)
pka: 6.19±0.10(Predicted)
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
InChIKey: MSSXBKQZZINCRI-UHFFFAOYSA-N
SMILES: N1=C(N2CCOCC2)N=C(N2CCOCC2)N=C1NC1=CC=C([N+]([O-])=O)C=C1

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Safety

WGK Germany: 3
HS Code: 2934.99.3900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0810
Product name: MHY 1485
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $75.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0810
Product name: MHY 1485
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $306
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.00554
Product name: mTOR Activator, MHY1485
Packaging: 10 mg
Price: $212
Updated: 2025/07/31

TCI Chemical

Product number: M3107
Product name: MHY 1485
Purity: >95.0%(HPLC)
Packaging: 25mg
Price: $183
Updated: 2025/07/31

TCI Chemical

Product number: M3107
Product name: MHY 1485
Purity: >95.0%(HPLC)
Packaging: 100mg
Price: $501
Updated: 2025/07/31

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MHY1485 Chemical Properties,Usage,Production

Description

MHY1485 is a cell-permeable activator of mTOR that has been shown to increase levels of cellular mTOR Ser²⁴⁴⁸ and downstream substrate 4E-BP Thr^37/46 phosphorylation in rat liver Ac2F cells. It can induce cellular LC3-II accumulation in Ac2F cells and has been shown to inhibit autophagy by suppressing the fusion between autophagosomes and lysosomes.

Uses

MHY1485 has been used:

to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation
to inhibit autophagy
as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Biochem/physiol Actions

MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.

in vivo

MHY1485 (intraperitoneal injection; 10?mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH). It increases p-mTOR and p-S6K1 expression levels, whereas LC3 expression shows no marked change compared to that in the control group^[3].

Animal Model:	4-week-old female ICR mice^[3]
Dosage:	10?mg/kg, 2 days
Administration:	Intraperitoneal injection
Result:	Suppressed the autophagy level following FSH treatment.?

IC 50

mTORC1; mTORC2; Autophagy

References

[1] YEON JA CHOI. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion.[J]. PLoS ONE, 2012: e43418. DOI:10.1371/journal.pone.0043418
[2] YUAN CHENG. Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators.[J]. PLoS ONE, 2015: e0117769. DOI:10.1371/journal.pone.0117769
[3] SAI ZHAO . MHY1485 activates mTOR and protects osteoblasts from dexamethasone[J]. Biochemical and biophysical research communications, 2016, 481 3: Pages 212-218. DOI:10.1016/j.bbrc.2016.10.104
[4] BO YANG. MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling[J]. Oncotarget, 2017, 8 1: 12775-12783. DOI:10.18632/oncotarget.14299
[5] CAIXIA LI Helmy M S. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose.[J]. American journal of physiology. Endocrinology and metabolism, 2015, 309 3: E302-10. DOI:10.1152/ajpendo.00603.2014

MHY1485 Preparation Products And Raw materials

Raw materials

Preparation Products

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MHY1485 Suppliers

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View Lastest Price from MHY1485 manufacturers

Career Henan Chemical Co

Product: 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine 326914-06-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

326914-06-1, MHY1485Related Search:

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE MIF Antagonist, ISO-1 Chloroquine diphosphate Thapsigargin

MHY1485

4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

MHY-1485;MHY 1485

1,3,5-Triazin-2-amine, 4,6-di-4-morpholinyl-N-(4-nitrophenyl)-

4,6-Bis(morpholin-4-yl)-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

MHY1485 USP/EP/BP

MHY1485, 10 mM in DMSO

mTOR Activator, MHY1485

MHY1485 ，S7811

326914-06-1

C17H21N7O4

Inhibitors