ChemicalBook > CAS DataBase List > N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

Product Name: N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
CAS No.: 164204-38-0
Chemical Name: N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
Synonyms: Phosphoramidon (Disodium);CRDWMOVRQCMROH-HIKRQZGHSA-N;N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt;N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
CBNumber: CB92744622
Molecular Formula: C23H35N3NaO10P
Formula Weight: 567.51
MOL File: 164204-38-0.mol

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N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Property

storage temp.: Desiccate at -20°C
solubility: ≥58.7 mg/mL in DMSO; insoluble in EtOH; ≥52.5 mg/mL in H2O
form: solid
color: White to off-white
Water Solubility: Soluble to 100 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15113
Product name: Phosphoramidon (sodium salt)
Purity: ≥98%
Packaging: 1mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 15113
Product name: Phosphoramidon (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 15113
Product name: Phosphoramidon (sodium salt)
Purity: ≥98%
Packaging: 10mg
Price: $296
Updated: 2024/03/01

Cayman Chemical

Product number: 15113
Product name: Phosphoramidon (sodium salt)
Purity: ≥98%
Packaging: 25mg
Price: $629
Updated: 2024/03/01

TRC

Product number: P359000
Product name: Phosphoramidon disodium salt
Packaging: 5mg
Price: $245
Updated: 2021/12/16

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N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Chemical Properties,Usage,Production

Description

Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases. Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with K_i values of 2 nM for both enzymes. It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (K_i = 3.5 μM). Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.

Uses

An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.

in vivo

Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats^[4].
Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats^[5].

Animal Model:	Male Sprague-Dawley rats^[4]
Dosage:	0.25 mg/kg per min
Administration:	Intravenous injection
Result:	Markedly suppressed the hypertensive effect of big endothelin-1.

IC 50

Microbial Metabolite

storage

Store at -20°C

References

[1]. ikegawa r, matsumura y, tsukahara y, et al. phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme. biochem biophys res commun, 1990, 171(2): 669-675.
[2]. matsumura y, ikegawa r, hisaki k, et al. conversion of big endothelin-1 to endothelin-1 by phosphoramidon-sensitive metalloproteinase derived from aortic endothelial cells. j cardiovasc pharmacol, 1991, 17 suppl 7: s65-7.
[3]. matsuura a, okumura h, ashizawa n, et al. big endothelin-1-induced sudden death is inhibited by phosphoramidon in mice. life sci, 1992, 50(21): 1631-1638.

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

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164204-38-0, N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)Related Search:

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

Phosphoramidon (Disodium)

CRDWMOVRQCMROH-HIKRQZGHSA-N

N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt

164204-38-0

C23H34N3Na2O10P

Inhibitors