N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
- Product Name
- N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
- CAS No.
- 164204-38-0
- Chemical Name
- N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
- Synonyms
- Phosphoramidon (Disodium);CRDWMOVRQCMROH-HIKRQZGHSA-N;N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt;N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1);N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
- CBNumber
- CB92744622
- Molecular Formula
- C23H35N3NaO10P
- Formula Weight
- 567.51
- MOL File
- 164204-38-0.mol
N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Property
- storage temp.
- Desiccate at -20°C
- solubility
- ≥58.7 mg/mL in DMSO; insoluble in EtOH; ≥52.5 mg/mL in H2O
- form
- solid
- Water Solubility
- Soluble to 100 mM in water
N-Bromosuccinimide Price
- Product number
- 15113
- Product name
- Phosphoramidon (sodium salt)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 15113
- Product name
- Phosphoramidon (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 15113
- Product name
- Phosphoramidon (sodium salt)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $296
- Updated
- 2024/03/01
- Product number
- 15113
- Product name
- Phosphoramidon (sodium salt)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $629
- Updated
- 2024/03/01
- Product number
- P359000
- Product name
- Phosphoramidon disodium salt
- Packaging
- 25mg
- Price
- $535
- Updated
- 2021/12/16
N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Chemical Properties,Usage,Production
Description
Neprilysin (NEP) and NEP2 are membrane-
Uses
An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.
storage
Store at -20°C
References
[1]. ikegawa r, matsumura y, tsukahara y, et al. phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme. biochem biophys res commun, 1990, 171(2): 669-675.
[2]. matsumura y, ikegawa r, hisaki k, et al. conversion of big endothelin-1 to endothelin-1 by phosphoramidon-sensitive metalloproteinase derived from aortic endothelial cells. j cardiovasc pharmacol, 1991, 17 suppl 7: s65-7.
[3]. matsuura a, okumura h, ashizawa n, et al. big endothelin-1-induced sudden death is inhibited by phosphoramidon in mice. life sci, 1992, 50(21): 1631-1638.