10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine

Product Name: 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
CAS No.: 55476-47-6
Chemical Name: 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
Synonyms: PSB-12062;PSB-12062 >=98% (HPLC);10-Tosyl-10H-phenoxazine;N-(p-Methylphenylsulfonyl)phenoxazine;10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine;10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]-;P2X Receptor,Inhibitor,PSB12062,PSB 12062,PSB-12062,P2XRs,inhibit
CBNumber: CB92751073
Molecular Formula: C19H15NO3S
Formula Weight: 337.39
MOL File: 55476-47-6.mol

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10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine Property

storage temp.: 2-8°C
solubility: DMSO: soluble2mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0753
Product name: PSB-12062
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0753
Product name: PSB-12062
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $375
Updated: 2024/03/01

AK Scientific

Product number: SYN5424
Product name: PSB-12062
Packaging: 50mg
Price: $406
Updated: 2021/12/16

ChemScene

Product number: CS-6918
Product name: PSB-12062
Purity: 99.06%
Packaging: 25mg
Price: $198
Updated: 2021/12/16

ChemScene

Product number: CS-6918
Product name: PSB-12062
Purity: 99.06%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

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10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine Chemical Properties,Usage,Production

Biological Activity

PSB-12062 is a potent and selective P2X4 antagonist with IC50 value of 1.38 μM for human P2X4.

in vitro

10-Tosyl-10H-phenoxazine shows similar potency in human, rat, and mouse species.It shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However,it is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).

target

IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)

10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine Preparation Products And Raw materials

Raw materials

Preparation Products

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10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine Suppliers

China 27 United States 4 Global 31

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55476-47-6, 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazineRelated Search:

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10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine

PSB-12062

10-Tosyl-10H-phenoxazine

N-(p-Methylphenylsulfonyl)phenoxazine

10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]-

PSB-12062 >=98% (HPLC)

P2X Receptor,Inhibitor,PSB12062,PSB 12062,PSB-12062,P2XRs,inhibit

55476-47-6