2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
- Product Name
- 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
- CAS No.
- 1414469-59-2
- Chemical Name
- 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
- Synonyms
- TAE-1;TAE-1 >=98% (HPLC);β-amyloid peptide,inhibit,Cholinesterase (ChE),TAE1,Amyloid-β,TAE-1,Abeta,Inhibitor,TAE 1;2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide;2,2',2"-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1- phenylenecarbonyloxy)]tris[N,N,N-trimethyl- ethanaminium] triiodid;2,2',2'-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethylethanaminium] iodide (1:3);2,2',2''-((4,4',4''-((1,3,5-Triazine-2,4,6-triyl)tris(oxy))tris(benzoyl))tris(oxy))tris(N,N,N-trimethylethan-1-aminium) iodide
- CBNumber
- CB92751088
- Molecular Formula
- C39H51I3N6O9
- Formula Weight
- 1128.57045
- MOL File
- 1414469-59-2.mol
2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 20464
- Product name
- TAE-1
- Packaging
- 5mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 20464
- Product name
- TAE-1
- Packaging
- 1mg
- Price
- $28
- Updated
- 2023/01/06
- Product number
- 20464
- Product name
- TAE-1
- Packaging
- 10mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 20464
- Product name
- TAE-1
- Packaging
- 25mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- T460315
- Product name
- TAE-1
- Packaging
- 5mg
- Price
- $285
- Updated
- 2021/12/16
2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Chemical Properties,Usage,Production
Biological Activity
tae-1 is an inhibitor of amyloid-β fibril formation and aggregation.alzheimer’s disease (ad), a progressive neurodegenerative disorder, is characterized by the cerebral accumulation of insoluble aggregates of amyloid-β peptides (aβ). although the precise mechanisms governing neuronal loss remains ambiguous, toxicity resulting from aβ-activated pathways is evident.
in vitro
in a previous study, the authors examined the effects of tae-1 on differentiated human sh-sy5y neuronal cells grown in tissue culture. results showed that the stimulation of neuronal cellular process length and branching was noted. moreover, the increased synaptophysin suggested that tae-1 could stimulate synapse formation. increased expression of map2 was also observed, indicating that tae-1 promoted the differentiation of human neurons. in addition, targeted ache inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes. it was found that at increasing tae-1concentrations, there was a corresponding decrease in the ache activity resulting in reduced amount of oxidizable thiocholine. the ic50 value was found to be 0.465 μm for tae-1 [1].
IC 50
0.3 ± 0.02 μm for ache; 3.9 ± 0.2 μm for buche
References
[1] veloso aj, chow am, dhar d, tang dw, ganesh hv, mikhaylichenko s, brown ir, kerman k. biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of alzheimer's disease. acs chem neurosci. 2013 jun 19;4(6):924-9.
2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Preparation Products And Raw materials
Raw materials
Preparation Products
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