ChemicalBook > CAS DataBase List > 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE

6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE

Product Name
6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE
CAS No.
386704-12-7
Chemical Name
6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE
Synonyms
6-(TRIFLUOROMETHYL)NICOTINALDEHYDE;5-Formyl-2-(trifluoromethyl)pyridine;6-trifluoromethyl nicotinic aldehyde;6-Trifluoromethylpyridine-3-aldehyde;6-(Trifluoromethyl)nicotinaldehyde 97%;6-(Trifluoromethyl)pyrdine-3-carbaldehyde;2-(trifluoromethyl)pyridine-5-carbaldehyde;6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE;2-(Trifluoromethyl)pyridine-5-carboxaldehyde;6-(TrifluoroMethyl)-3-pyridinecarboxaldehyde
CBNumber
CB9277223
Molecular Formula
C7H4F3NO
Formula Weight
175.11
MOL File
386704-12-7.mol
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6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE Property

Melting point:
52-56 °C
Boiling point:
72 °C
Density 
1.369±0.06 g/cm3(Predicted)
Flash point:
93 °C
storage temp. 
2-8°C
solubility 
soluble in Methanol
pka
-1.25±0.22(Predicted)
form 
Solid
color 
White to Almost white
Sensitive 
Air Sensitive
InChI
InChI=1S/C7H4F3NO/c8-7(9,10)6-2-1-5(4-12)3-11-6/h1-4H
InChIKey
MRPAGRCGPAXOGS-UHFFFAOYSA-N
SMILES
C1=NC(C(F)(F)F)=CC=C1C=O
CAS DataBase Reference
386704-12-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-43-25
Safety Statements 
26-36/37/39-36/37-28
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
640085
Product name
6-(Trifluoromethyl)pyridine-3-carboxaldehyde
Purity
95%
Packaging
1g
Price
$161
Updated
2023/06/20
Sigma-Aldrich
Product number
640085
Product name
6-(Trifluoromethyl)pyridine-3-carboxaldehyde
Purity
95%
Packaging
5g
Price
$699
Updated
2023/06/20
TCI Chemical
Product number
T2838
Product name
6-(Trifluoromethyl)-3-pyridinecarboxaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$125
Updated
2025/07/31
TCI Chemical
Product number
T2838
Product name
6-(Trifluoromethyl)-3-pyridinecarboxaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$446
Updated
2025/07/31
TRC
Product number
T791510
Product name
6-(Trifluoromethyl)pyridine-3-carboxaldehyde
Packaging
1g
Price
$75
Updated
2021/12/16
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6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production

Uses

6-(Trifluoromethyl)pyridine-3-carboxaldehyde is a reagent in the preparation of piperidine derivatives as possible Alzheimer’s treatment agents.

Synthesis

386704-04-7

386704-12-7

General procedure for the synthesis of 6-(trifluoromethyl)pyridine-3-carboxaldehyde from 6-(trifluoromethyl)-3-pyridine methanol: Intermediate 174: 6-(Trifluoromethyl)nicotine derivative; 800 mg of 6-(trifluoromethyl)pyridin-3-yl)methanol (Intermediate 173, 4.52 mmol) was dissolved in 50 mL of dichloromethane (DCM) and cooled to 0°C. To this solution was added 2 g of manganese dioxide (MnO2, 23 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated at room temperature to give 750 mg (95% yield) of 6-trifluoromethylpyridine-3-carbaldehyde as a white solid. The product was characterized by 1H-NMR (CDCl3): δ 7.88-7.90 (1H, d), 8.36-8.38 (1H, d), 9.20 (1H, s), 10.22 (1H, s); TLC (DCM/MeOH 10:1) showed Rf = 0.9.

References

[1] Patent: WO2008/148853, 2008, A1. Location in patent: Page/Page column 182
[2] Patent: US2009/239905, 2009, A1. Location in patent: Page/Page column 14
[3] Patent: WO2007/110667, 2007, A1. Location in patent: Page/Page column 27

6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

5-Bromo-2-iodopyridine Magnesium nitrate Hexane Nitrogen N-Methyl-2-pyrrolidone N,N-Dimethylformamide Sodium sulfate Cuprous iodide Sodium chloride Potassium fluoride Potassium carbonate Sodium Tetrahydrofuran Iodine Ethyl acetate Sodium bicarbonate Dichloromethane Chlorodifluoroacetic acid ethyl ester Magnesium sulfate n-Butyllithium 2-Chloropropane

Preparation Products

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6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE Suppliers

China 169 France 1 Germany 3 India 6 Italy 1 Japan 1 Switzerland 1 United Kingdom 9 United States 19 Global 210
Hangzhou Cheminspire Technology Co., Ltd.
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0571-89081561; 10006559855
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0571 89081561
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info@cheminspire.com
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China
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Taizhou Yikang Chemical Co., Ltd.
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0576-88501337 18906763631
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+86-576-88501337
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sales@yikangchemicals.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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Energy Chemical
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Capot Chemical Co., Ltd
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Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
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+86-10-82967029
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2355560935@qq.com
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54098501
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+86-21-54096319
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View Lastest Price from 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
6-(Trifluoromethyl)nicotinaldehyde 386704-12-7
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-24
Sach biotech Co.,Ltd
Product
6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE 386704-12-7
Price
US $200.00-140.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10mt
Release date
2025-06-06
Dideu Industries Group Limited
Product
6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE 386704-12-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-26

386704-12-7, 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDERelated Search:

6-(Trifluoromethyl)-1-indanone 6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL [6-(trifluoromethoxy)pyridin-2-yl]methanamine [6-(trifluoromethoxy)pyridin-3-yl]methanamine 2-(Trifluoromethyl)pyridine-3-carBoxaldehyde 2-CHLORO-5-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE,Chloro-5-(trifluoromethyl)pyridine-2-carboxaldehyde 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE 3-(Trifluoromethyl)pyridine-2-carboxaldehyde 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)BENZYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 6-HYDROXY-5-(2-HYDROXYBENZOYL)-2-(TRIFLUOROMETHYL)NICOTINIC ACID N-BENZYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-METHOXY-N-METHYL-N'-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]UREA N-(2,6-DIMETHYLPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(2,4-DIFLUOROPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N,N-DIMETHYL-N'-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]UREA N-(4-CHLOROBENZYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE METHYL N-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]CARBAMATE

  • 6-(TrifluoroMethyl)-3-pyridinecarboxaldehyde
  • 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE, 6-TRIFLUOROMETHYL-PYRIDINE-3-CARBALDEHYDE
  • 6-(Trifluoromethyl)pyridine-3-carboxaldehyde 95%
  • 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE
  • 6-(TRIFLUOROMETHYL)NICOTINALDEHYDE
  • 2-(Trifluoromethyl)pyridine-5-carboxaldehyde
  • 2-(Trifluoromethyl)pyridine-5-carboxaldehyde 97%
  • 2-(Trifluoromethyl)pyridine-5-carboxaldehyde97%
  • 5-Formyl-2-(trifluoromethyl)pyridine, 6-(Trifluoromethyl)pyridine-3-carboxaldehyde
  • 6-(Trifluoromethyl)nicotinaldehyde 97%
  • 2-(Trifluoromethyl)pyridine-5-carboxaldehyde, 5-Formyl-2-(trifluoromethyl)pyridine, 6-(Trifluoromethyl)pyridin-3-carboxaldehyde
  • 5-Formyl-2-(trifluoromethyl)pyridine
  • 6-(Trifluoromethyl)pyrdine-3-carbaldehyde
  • 3-Pyridinecarboxaldehyde, 6-(trifluoromethyl)-
  • 2-Hydroxy-2',5,5'-trichlorobiphenyl@100 μg/mL in Isooctane
  • 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE ISO 9001：2015 REACH
  • 6-trifluoromethyl nicotinic aldehyde
  • 6-Trifluoromethylpyridine-3-aldehyde
  • 2-(trifluoromethyl)pyridine-5-carbaldehyde
  • 386704-12-7
  • Fluorine series
  • Heterocyclic Compounds
  • Aldehydes
  • Pyridines
  • Building Blocks
  • Pyridine