4-METHOXYBENZAMIDINE, HYDROCHLORIDE

4-METHOXYBENZAMIDINE, HYDROCHLORIDE Property

Melting point:

218-220°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

λmax

261nm(H2O)(lit.)

Safety

Hazard Codes 

Xn

Risk Statements 

22

HazardClass 

IRRITANT

HS Code 

2916310090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

4-METHOXYBENZAMIDINE, HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Solid

Uses

4-Methoxybenzamidine Hydrochloride (cas# 51721-68-7) is a compound useful in organic synthesis.

Synthesis

General procedure for the synthesis of 4-methoxybenzenecarbamidine hydrochloride from 4-methoxybenzyl cyanide: 4-methoxybenzyl cyanide (2.1 g, 15.7 mmol) was mixed with sodium methanolate (86 mg, 1.57 mmol) in 20 mL of anhydrous methanol, and the reaction was stirred for 48 hours at room temperature. Subsequently, ammonium chloride (0.84 g, 15.7 mmol) was added to the reaction system and stirring was continued for 24 hours. After completion of the reaction, the precipitate was collected by filtration, washed with ether and dried under vacuum to afford the target product 4-methoxybenzenecarboximidamide hydrochloride (1.3 g, 44.5% yield). Mass spectrum (ESI) m/z: 151.1 ([M+H]+).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 783 - 795
[2] Journal of the American Chemical Society, 1985, vol. 107, # 9, p. 2743 - 2748
[3] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 3, p. 613 - 623
[4] Collection of Czechoslovak Chemical Communications, 1981, vol. 46, # 4, p. 933 - 940
[5] Patent: US6218538, 2001, B1