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CHOLESTA-3,5-DIENE

Product Name
CHOLESTA-3,5-DIENE
CAS No.
747-90-0
Chemical Name
CHOLESTA-3,5-DIENE
Synonyms
Cholestadiene;CHOLESTERILENE;CHOLESTERYLENE;3,5-CHOLESTADIEN;3,5-CHOLESTADIENE;CHOLEST-3,5-DIENE;CHOLESTA-3,5-DIENE;Cholestane-3,5-diene;delta-3,5-Cholestadiene;delta(Sup3,5)-Cholestadiene
CBNumber
CB9284144
Molecular Formula
C27H44
Formula Weight
368.64
MOL File
747-90-0.mol
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CHOLESTA-3,5-DIENE Property

Melting point:
78-80 °C (lit.)
Boiling point:
433.93°C (rough estimate)
Density 
0.9250
refractive index 
1.4922 (estimate)
storage temp. 
-20°C
form 
Solid
color 
White to off-white
biological source
natural (organic)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
FZ5600000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C6012
Product name
Cholesta-3,5-diene
Purity
≥93% (HPLC)
Packaging
25mg
Price
$184
Updated
2025/07/31
Sigma-Aldrich
Product number
C6012
Product name
Cholesta-3,5-diene
Purity
≥93% (HPLC)
Packaging
100mg
Price
$556
Updated
2025/07/31
TRC
Product number
C431508
Product name
Cholesta-3,5-diene
Packaging
50mg
Price
$225
Updated
2021/12/16
TRC
Product number
C431508
Product name
Cholesta-3,5-diene
Packaging
10mg
Price
$80
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0000261
Product name
CHOLESTA-3,5-DIENE
Purity
95.00%
Packaging
25MG
Price
$655.74
Updated
2021/12/16
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CHOLESTA-3,5-DIENE Chemical Properties,Usage,Production

Uses

Cholesta-3,5-diene was used as standard in HPLC in quality analysis of different types of olive oils and edible fats.

Definition

ChEBI: Cholesta-3,5-diene is a cholestanoid.

Biochem/physiol Actions

Cholesta-3,5-diene is an oxysterol, a cholesterol derivative by auto-oxidation. Oxysterols are non-genomic regulators of cholesterol homeostasis. The biological effects include protein prenylation, apoptosis, modulation of sphingolipid metabolism and platelet aggregation. Oxysterols bind to liver X receptors, modulate cholesterol efflux and decrease the uptake of cholesterol by the cells.

in vivo

Neutrophil Recruitment: Cholesta-3,5-diene (30 μg/ml; topical application; single dose) promotes neutrophil recruitment to tailfin wounds in transgenic zebrafish larvae (Tg(mpx:GFP)) by 6 h post-treatment1.
Tissue Regeneration: Cholesta-3,5-diene (30 μg/ml; topical application; single dose) does not enhance tissue regeneration in zebrafish tailfin wounds, unlike the lipid fraction Ft containing Cholesta-3,5-diene1.

Animal Model:Transgenic zebrafish larvae (Tg(mpx:GFP), 4 days post-fertilization, male/female mixed, 200-300 mg)[1]
Dosage:30 μg/mL Cholesta-3,5-diene (dissolved in ethanol, diluted in E2 medium)
Administration:Topical application to transected tailfin immediately after wounding, single dose
Result:Significantly increased neutrophil accumulation at the wound site by 6 h post-treatment (2-fold vs. vehicle control.
No effect was observed in uninjured tailfins[1].
Animal Model:Transgenic zebrafish larvae (Tg(mpx:GFP), 4 days post-fertilization, male/female mixed, 200-300 mg)1
Dosage:30 μg/mL Cholesta-3,5-diene (dissolved in ethanol, diluted in E2 medium)
Administration:Topical application to transected tailfin immediately after wounding, single dose
Result:Did not promote significant tissue regeneration at 2 or 6 days post-treatment, unlike the lipid fraction Ft (which showed dose-dependent regeneration).
Resulted maximum regeneration with Ft of 50 μg/mL.

CHOLESTA-3,5-DIENE Preparation Products And Raw materials

Raw materials

Preparation Products

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CHOLESTA-3,5-DIENE Suppliers

China 30 India 1 Norway 1 Switzerland 1 United Kingdom 2 United States 10 Global 45
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747-90-0, CHOLESTA-3,5-DIENERelated Search:

Benzoic acid cholesta-5,7-diene-3β-yl ester,Cholesta-5,7-diene-3β-ol benzoate Acetic acid cholesta-5,7-diene-3β-yl ester (22E,24R)-24-Methyl-5α-cholesta-7,22-diene-3β,5,6β-triol 3,5-CHOLESTADIEN-3-OL 3-ACETATE cholesta-5,7-diene-1alpha,3beta-diyl diacetate ,Diacetic acid cholesta-5,7-diene-1α,3β-diyl ester,Cholesta-5,7-diene-1α,3β-diol diacetate cholesta-4,6-diene-3beta-ol Cholesta-2,4-diene CHOLESTA-3,5-DIENE-7-ONE-25,26,26,26,27,27,27-D7 3,3'-BIS(3,5-CHOLESTADIENE) CHOLESTA-3,5-DIENE cholesta-3,5-dien-7-one Cholesta-4,6-diene (24R)-Cholesta-5,7-diene-3β,24,25-triol Cholesta-4,6-diene-3β-ol acetate (22E,24S)-24-Ethyl-5α-cholesta-7,22-diene-3β,5,6β-triol 3,6-diacetate 5α-Cholesta-2,6-diene 5α-Cholesta-7,14-diene-3β,5,6α,20,25-pentol 3-(dihydrogen phosphate) 3β-(Trimethylsilyloxy)cholesta-5,24-diene

  • Cholestadiene
  • delta-(sup3,5)-cholestadien
  • delta(Sup3,5)-Cholestadiene
  • delta-<sup>3,5</sup>-Cholestadien
  • delta-3,5-Cholestadiene
  • CHOLESTERILENE
  • CHOLESTA-3,5-DIENE
  • CHOLEST-3,5-DIENE
  • CHOLESTERYLENE
  • 3,5-CHOLESTADIEN
  • 3,5-CHOLESTADIENE
  • CHOLESTA-3-5-DIENE CRYSTALLINE
  • CHOLESTA-3,5-DIENE, >=93% (HPLC)
  • Cholestane-3,5-diene
  • (8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene
  • Zoledronic Acid Impurity 6 Chloride
  • 747-90-0
  • C27H44
  • BioChemical
  • Biochemicals and Reagents
  • Sterols
  • Cholesterol and Derivatives
  • Lipids
  • Cholesterol and Derivatives
  • Lipids
  • Sterols