Tetramisole hydrochloride

Product Name: Tetramisole hydrochloride
CAS No.: 5086-74-8
Chemical Name: Tetramisole hydrochloride
Synonyms: TETRAMISOLE HCL;Tetraimidazole Hydrochloride;r8299;R-829;nilverm;citarin;nilverom;ripercol;ripereol;Concurat
CBNumber: CB9285459
Molecular Formula: C11H13ClN2S
Formula Weight: 240.75
MOL File: 5086-74-8.mol

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Tetramisole hydrochloride Property

Melting point:: 266-267 °C(lit.)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Methanol (Slightly), Water (Slightly, Heated)
form: Solid
color: White to Off-White
Water Solubility: 200 g/L (20 ºC)
Merck: 13,5480
BRN: 4358989
Stability:: Hygroscopic
InChI: InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H
InChIKey: LAZPBGZRMVRFKY-UHFFFAOYSA-N
SMILES: C1N2C(=NC(C2)C2=CC=CC=C2)SC1.[H]Cl
CAS DataBase Reference: 5086-74-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36
WGK Germany: 3
RTECS: NJ5950000
HS Code: 29349990
Toxicity: LD50 in mice, rats (mg/kg): 22, 24 i.v.; 84, 130 s.c.; 210, 480 orally (Thienpoint)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T1512
Product name: Tetramisole hydrochloride
Purity: phosphatase inhibitor
Packaging: 2g
Price: $55.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: T1512
Product name: Tetramisole hydrochloride
Purity: phosphatase inhibitor
Packaging: 5g
Price: $74.6
Updated: 2024/03/01

TCI Chemical

Product number: T3663
Product name: Tetramisole Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 10g
Price: $74
Updated: 2024/03/01

Sigma-Aldrich

Product number: T1512
Product name: Tetramisole hydrochloride
Purity: phosphatase inhibitor
Packaging: 10g
Price: $108
Updated: 2024/03/01

TRC

Product number: T305680
Product name: Tetramisole hydrochloride
Packaging: 50g
Price: $155
Updated: 2021/12/16

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Tetramisole hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Tetraimidazole hydrochloride is a white to pale cream crystalline powder, bitter and astringent, easily soluble in water , Methanol, slightly soluble in ethanol, insoluble in acetone. acid solutions are stable; however, hydrolysis occurs under alkaline conditions. The rate of hydrolysis increases with pH and temperature. It is used as levamisole intermediate, anthelmintic drug.

Uses

Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. It is suitable for inhibition of various alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor)(Intestinal alkaline phosphatases are only slightly inhibited.). Tetramisole has biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.

Definition

ChEBI: Tetramisole hydrochloride is an organic molecular entity. It is a broad-spectrum veterinary anthelmintic with high efficiency and low toxicity.

Application

Tetramisole is an alkaline phosphatase inhibitor. It is a racemic mixture of (+) and (-) isomers. The (-) isomer (levamisole) accounts for most of the biological activity of tetramisole.
Tetramisole has been used to inhibit alkaline phosphatase in the effective range of 0.4 – 2 mM. Inhibition of intestinal alkaline phosphate requires higher concentrations. In addition to its use in enzyme and protein phosphorylation studies, tetramisole has been used to study membrane, tissue and animal systems.
Tetramisole is an anthelminthic agent used in veterinary applications to treat helminth or worm infections.

brand name

Ergamisol (Janssen).

in vitro

Tetramisole hydrochloride at 67.5 mg/kg is 88.8% effective against immature and 99.7% effective against adult Libyostrongylus douglassi of the ostrich. A dose of up to 408 mg/kg tetramisole hydrochloride had no adverse effects on young birds but at 529 mg/kg was lethal to both chicks and adult ostriches. The efficacy of pyrantel tartrate was erratic. At 50 - 60 mg/kg it was 72.3% effective against immatures and 50.2% effective against adult worms. At 100 mg/kg it fell to 43.6% against immature, but rose to 77.3% against adult worms. Pyrantel tartrate at 100 mg/kg caused the death .of three out of four chicks. The macroscopic lesions of the disease ""vrotmaag"" caused by L. douglassi are descriptionbed as well as some of the other pathological lesions observed at autopsy.

Mode of action

Tetramisole HCl inhibits parasitic worm growth by acting as an agonist to nicotinic acetylcholine receptors leading to paralysis. The mechanism of action for anticancer activity is unknown.

Tetramisole hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Tetramisole hydrochloride Suppliers

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View Lastest Price from Tetramisole hydrochloride manufacturers

Dorne Chemical Technology co. LTD

Product: Tetramisole hydrochloride 5086-74-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2024-03-26

Guangdong Junhua Chemical Co., Ltd

Product: Tetramidazole hydrochloride 5086-74-8
Price: US $160.00-35.00/kg
Min. Order: 1kg
Purity: 99％pure
Supply Ability: 20 tons
Release date: 2024-12-11

Guangdong Junhua Chemical Co., Ltd

Product: Tetramidazole hydrochloride 5086-74-8
Price: US $160.00-35.00/kg
Min. Order: 1kg
Purity: 99％pure
Supply Ability: 20 tons
Release date: 2024-12-17

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