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Bulleyaconitine A

Product Name
Bulleyaconitine A
CAS No.
107668-79-1
Chemical Name
Bulleyaconitine A
Synonyms
Bulleyaconitine;BULLEYACONITINE A;Bulleyaconi cine A;BULLEYACONITINE A(P);Bulleyaconitine A-RM;BULLEYACONITINE A(RG);Aconitane,Methanone deriv;Bulleyaconitine A USP/EP/BP;crassicauline A(bulleyaconitine;(-)-Syringaresinol 4-O-β-D-glucopyranosi
CBNumber
CB9291737
Molecular Formula
C35H49NO9
Formula Weight
627.76
MOL File
107668-79-1.mol
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Bulleyaconitine A Property

Boiling point:
690.9±55.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Store at 2-8°C
solubility 
DMSO: 125 mg/mL (199.12 mM)
form 
Solid
pka
13.12±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B689710
Product name
BulleyaconitineA
Packaging
10mg
Price
$140
Updated
2021/12/16
Usbiological
Product number
300033
Product name
Bulleyaconitine A
Packaging
20mg
Price
$280
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB65643
Product name
Bulleyaconitine A
Packaging
10mg
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-3592
Product name
BulleyaconitineA
Purity
99.09%
Packaging
10mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB65643
Product name
Bulleyaconitine A
Packaging
25mg
Price
$130
Updated
2021/12/16
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Bulleyaconitine A Chemical Properties,Usage,Production

Description

Bulleyaconitine A is an aconitine-type two terpene alkaloid, and its molecular formula is C35H49NO10.?As early as 1980, bulleyaconitine was separated and extracted from a traditional analgesic and anti-inflammatory herb in the west of Yunnan called dianxi dula (or dianxi wutou) (Aconitum bulleyanum Diels), by the Kunming Institute of Botany, Chinese Academy of Sciences . At present, bulleyaconitine A can be separated from Aconitum plants, for example, dianxi wutou (Aconitum bulleyanum Diels), cujing wutou (Aconitum crassicaule W.T.?Wang), changhui wutou (Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels).

Physical properties

Appearance: white powder. Solubility: soluble in methanol, ethanol, chloroform, and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or dilute sulfuric acid . Melting point: 160–165?°C

History

In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan Honghe Pingbian pharmaceutical company, where it obtained the trade name “Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown a great market growth and competitive power, owing to its exact curative effect and rapid clinical promotion in chronic disease and rheumatic immune disease.

Uses

Bulleyaconitine A is an agent that expresses long-lasting local anaesthetic properties used in the treatment of chronic pain and arthritis. Commonly used in China as a traditional medicine.

Pharmacology

1. Anti-inflammatory and analgesic effect. Bulleyaconitine A plays a significant anti-inflammatory effect by inhibiting the release of prostaglandins. The analgesic effect may be related to the rivalry of 5-HT and the inhibition of inflammatory chemokines in the brain, because inhibition of PGE2 release may lead to disinhibition of β-endorphin . Further studies showed that bulleyaconitine A achieved the analgesic effect by effectively reducing sodium ion current, the electrophysiological basis on which pain conduction is dependent . Zhanguo Niu et?al. found that bulleyaconitine A could be used to treat mild and moderate burn pain, with less adverse reactions and no addiction . Thus, bulleyaconitine A may be suitable for long-term use as a choice of analgesic therapy for burn pain. Recently, through clinical observation on the effect of bulleyaconitine A treatment in acute gouty arthritis, some scholars discovered that bulleyaconitine A brought about good effect and could effectively improve the clinical symptoms of patients by taking 0.4?mg bulleyaconitine A orally three times in daily .
2. Immune regulation. Bulleyaconitine A has obvious inhibitory effects to immune cells involved in joint inflammation, which may have a close relationship to its clinical anti-inflammatory effect. Ye Lu et?al. studied the influence of bulleyaconitine A on partial immune functions of BALB/c mice and found that 0.32?mg/kg bulleyaconitine A inhibits some immune functions of BALB/c mice . Moreover, it was reported that bulleyaconitine A significantly inhibited the phagocytic function and the ability to secrete nitric oxide (NO) of macrophages .
3. Other pharmacological effects. An injection of 0.1 mg/kg bulleyaconitin A in fasting rat can inhibit the formation of corneal neovascularization induced by alkali burn . Bulleyaconitine A also has local anesthesia and antipyretic effect. Besides, bulleyaconitine A can be used for the treatment of lumbar muscle strain, scapulohumeral periarthritis, and sprain of limbs.

Clinical Use

1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good curative effects.
2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its effects by regulating the sodium ion channel. So there is little psychological dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal adverse reactions and drug dependence or other potential dangers caused by NSAID and opioid analgesics.

Bulleyaconitine A Preparation Products And Raw materials

Raw materials

Preparation Products

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Bulleyaconitine A Suppliers

Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
Apin Chemicals Ltd.
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6807
Advantage
42
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View Lastest Price from Bulleyaconitine A manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.
Product
Bulleya conitine A 107668-79-1
Price
US $120.00/KG
Min. Order
1250KG
Purity
99%
Supply Ability
330T
Release date
2023-06-08
Shanghai Standard Technology Co., Ltd.
Product
Bulleyaconitine A 107668-79-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
Bulleyaconitine A 107668-79-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

107668-79-1, Bulleyaconitine ARelated Search:


  • 16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-y-6
  • methanone,((1-alpha,6-alpha,14-alpha,16-beta)-8-(acetyloxy)-20-ethyl-13-hydrox
  • BULLEYACONITINE A
  • METHANONE, [(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)-
  • BULLEYACONITINE A: METHANONE, [(1,6,14,16) -8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)-,
  • BULLEYACONITINE A(P)
  • 20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-
  • Methanone, [(1α,6α,14α,16β) -8-(acetyloxy)-
  • Bulleyaconi cine A
  • BULLEYACONITINE A(RG)
  • Aconitane,Methanone deriv
  • Methanone, [(1a,6a,14a,16b)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-
  • Bulleyaconitine
  • ((1-α,6-α,14-α,16-β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-methanone
  • Bulleyaconitine A, 98%, from Aconitum kusnezoffii Rchb.
  • crassicauline A(bulleyaconitine
  • Methanone, [(1α,6α,14α,16β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl) aconitan-14-yl](4-methoxyphenyl)-
  • Bulleyaconitine A USP/EP/BP
  • (-)-Syringaresinol 4-O-β-D-glucopyranosi
  • Bulleyaconitine A-RM
  • 107668-79-1
  • 79572-91-9
  • C35H49NO9
  • standardized herbal extract
  • Inhibitors
  • Natural Plant Extract
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).