ChemicalBook > CAS DataBase List > Poly(1-vinylpyrrolidone-co-vinyl acetate)

Poly(1-vinylpyrrolidone-co-vinyl acetate)

Product Name
Poly(1-vinylpyrrolidone-co-vinyl acetate)
CAS No.
25086-89-9
Chemical Name
Poly(1-vinylpyrrolidone-co-vinyl acetate)
Synonyms
VP/VA COPOLYMER;pvp-va;e335;kollidonva64;i735;i635;i535;e535;s630;kolima75
CBNumber
CB9295023
Molecular Formula
C10H15NO3
Formula Weight
197.23
MOL File
25086-89-9.mol
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Poly(1-vinylpyrrolidone-co-vinyl acetate) Property

Density 
1.27 g/mL at 25 °C(lit.)
Tg
108
refractive index 
1.4300 to 1.4380
Flash point:
72 °F
solubility 
Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
form 
powder
color 
White
Stability:
Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
InChI
InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChIKey
FYUWIEKAVLOHSE-UHFFFAOYSA-N
SMILES
C(N1CCCC1=O)=C.O(C=C)C(=O)C
LogP
0.370 (est)
EPA Substance Registry System
Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
10-36/37/38-67-36-11-22
Safety Statements 
22-24/25-36/37/39-26-16
RIDADR 
UN 1987 3/PG 2
WGK Germany 
1
RTECS 
AH3539000
TSCA 
TSCA listed
HazardClass 
3
PackingGroup 
II
HS Code 
29349990
Toxicity
LD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
190837
Product name
Poly(1-vinylpyrrolidone-co-vinyl acetate) solution
Purity
average Mw ~13,000 (GPC vs. poly(ethylene oxide)), 50 wt. % in isopropanol
Packaging
500g
Price
$126.6
Updated
2024/03/01
Sigma-Aldrich
Product number
1148500
Product name
Poly(1-vinylpyrrolidone-co-vinyl acetate) solution
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$491
Updated
2024/03/01
TCI Chemical
Product number
P0382
Product name
Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
P0382
Product name
Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol)
Packaging
500g
Price
$70
Updated
2024/03/01
scipoly
Product number
373
Product name
N-Vinylpyrrolidone/vinyl acetate copolymer
Packaging
250g
Price
$37
Updated
2024/07/03
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Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties,Usage,Production

Chemical Properties

white powder

Chemical Properties

Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.

Uses

Poly(1-vinylpyrrolidone-co-vinyl acetate)

Uses

Copovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.

Production Methods

Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.

General Description

～1:2.4 mole ratio of VP:VA

Pharmaceutical Applications

Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.

Safety Profile

Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.

Safety

Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.
LD50 (rat, oral): >0.63 g/kg

Solubility in organics

Acetone, chloroform, methanol, THF, water

Solubility in organics

THF (above 68C)

Solubility in organics

THF, water

storage

Copovidone is stable and should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.

Regulatory Status

Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).

Poly(1-vinylpyrrolidone-co-vinyl acetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Poly(1-vinylpyrrolidone-co-vinyl acetate) Suppliers

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View Lastest Price from Poly(1-vinylpyrrolidone-co-vinyl acetate) manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Poly(1-vinylpyrrolidone-co-vinyl acetate) 25086-89-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Poly(1-vinylpyrrolidone-co-vinyl acetate) 25086-89-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-07
Baoji Guokang Bio-Technology Co., Ltd.
Product
Poly(1-vinylpyrrolidone-co-vinyl acetate) 25086-89-9
Price
US $16.50/KG
Min. Order
25KG
Purity
98%
Supply Ability
1-10000kg
Release date
2021-06-08

25086-89-9, Poly(1-vinylpyrrolidone-co-vinyl acetate)Related Search:

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