FLECAINIDE ACETATE

ChemicalBook > CAS DataBase List > FLECAINIDE ACETATE

Product Name: FLECAINIDE ACETATE
CAS No.: 54143-56-5
Chemical Name: FLECAINIDE ACETATE
Synonyms: FLAC;Apocard;Tambocor;r-818;Ecrinal;Almarytm;Flucarney Acetate;FLECAINIDE ACETATE;Flecainide-d4 Acetate;Flecainide acetate CRS
CBNumber: CB9295801
Molecular Formula: C19H24F6N2O5
Formula Weight: 474.39
MOL File: 54143-56-5.mol

Less

FLECAINIDE ACETATE Property

Melting point:: 145-147℃
storage temp.: 2-8°C
solubility: Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid.
form: Solid
color: White
Water Solubility: Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water.
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-63
Safety Statements: 22-26-36/37/39-45-46
RIDADR: 3249
WGK Germany: -
RTECS: CV5792550
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2933399090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F6777
Product name: Flecainide acetate salt
Packaging: 25mg
Price: $166
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2921
Product name: Flecainide Acetate
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $207
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1270800
Product name: Flecainide acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP676
Product name: Flecainide acetate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $259
Updated: 2023/06/20

Alfa Aesar

Product number: J63527
Product name: Flecainide acetate, 98%
Packaging: 100mg
Price: $238
Updated: 2024/03/01

Less

FLECAINIDE ACETATE Chemical Properties,Usage,Production

Description

Flecainide acetate (54143-56-5) is an open Na+?channel blocker that inhibits fast Na+?current in cardiac muscle in a use- and concentration-dependent manner.1?Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG potassium channels at clinically relevant concentrations.4

Chemical Properties

White or almost white, very hygroscopic, crystalline powder.

Uses

Class I antiarrhythmic.

Uses

Flecainide acetate is used as a sodium channel blocker and as an anti-arrhythmic. In general, it is used to regulate heartbeats of the upper heart and lower heart chambers. It can also be used to slow down an overactive heart. It is also useful in the treatment of ventricular tachycardias and ventricular arrhythmias.

Definition

ChEBI: An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).

brand name

Tambocor (3M Pharmaceuticals).

General Description

Flecainide acetate, N-(2-piperidinylmethyl)-2,5-bis (2,2,2-trifluoroethoxy)benzamide monoacetate(Tambocor), is a class IC antiarrhythmic drug withlocal anesthetic activity; it is a chemical derivative of benzamide.The drug undergoes biotransformation, forming ameta-O-dealkylated compound, whose antiarrhythmic propertiesare half as potent as those of the parent drug, and ameta-O-dealkylated lactam of flecainide with little pharmacologicalactivity. Flecainide acetate is given orally to suppresschronic ventricular ectopy and ventricular tachycardia.It has some limitations because of CNS side effects.

Biological Activity

Open Na + channel blocker that inhibits fast Na + current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.

Biochem/physiol Actions

Class IC antiarrhythmic agent; sodium channel blocker

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: concentration increased by amiodarone - halve dose of flecainide; increased myocardial depression with other anti-arrhythmics.
Antidepressants: concentration increased by fluoxetine; increased risk of ventricular arrhythmias with tricyclics.
Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid.
Antihypertensives: increased myocardial depression and bradycardia with beta-blockers; increased myocardial depression and asystole with verapamil.
Antimalarials: concentration increased by quinine; avoid with artemether/lumefantrine.
Antimuscarinics: increased risk of ventricular arrhythmias with tolterodine.
Antipsychotics: increased risk of ventricular arrhythmias with antipsychotics that prolong the QT interval and phenothiazines; increased risk of arrhythmias with clozapine.
Antivirals: concentration possibly increased by fosamprenavir, indinavir, lopinavir, ritonavir and saquinavir, increased risk of ventricular arrhythmias - avoid; use telaprevir with caution.
Diuretics: increased cardiac toxicity if hypokalaemia occurs.

Metabolism

Flecainide is extensively metabolised (subject to genetic polymorphism), the 2 major metabolites being m-Odealkylated flecainide and m-O-dealkylated lactam of flecainide, both of which may have some activity. Its metabolism appears to involve the cytochrome P450 isoenzyme CYP2D6, which shows genetic polymorphism.
Flecainide is excreted mainly in the urine, approximately 30% as unchanged drug and the remainder as metabolites. About 5% is excreted in the faeces. Haemodialysis removes only about 1% of unchanged flecainide.

storage

Desiccate at +4°C

References

1) Rouet and Ducouret (1994), Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle; J. Cardiovasc. Pharmacol.,?24?177 2) Singh?et al. (1984),?The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions; Ann. N.Y. Acad. Sci.,?432?210 3) Banitt?et al.?(1977),?Anti-arrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides; J. Med. Chem.,?20?821 4) Melgari?et al.?(2015),?Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide; J. Mol. Cell. Cardiol.,?86?42

FLECAINIDE ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

FLECAINIDE ACETATE Suppliers

Argentina 2 Australia 1 Canada 1 CHINA 91 Czech Republic 1 Europe 3 France 4 Germany 6 India 30 Italy 4 Japan 1 Mexico 1 Poland 1 South Korea 1 Spain 1 Switzerland 1 The Netherlands 1 United Arab Emirates 1 United Kingdom 12 United States 39 Global 202

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 17501653715
Email: xingui2022@126.com
Country: China
ProdList: 10021
Advantage: 58

Shanghai Synteam Biochem CO.,ltd

Tel: +86-021-58380978 +86-18017016373
Fax: 021-58380978
Email: info@systeambc.com
Country: China
ProdList: 941
Advantage: 50

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973186 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 18338
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13320
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15084
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6038 18902104717
Email: sales@heowns.com
Country: China
ProdList: 21085
Advantage: 60

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4391
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9639
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Baoji Guokang Bio-Technology Co., Ltd.

Tel: 0917-3909592 13892490616
Fax: 09173909592
Email: gksales1@gk-bio.com
Country: China
ProdList: 9314
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15354
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 7724
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Shanghai Jiegu Biotechnology Co., Ltd.

Tel: 021-51698675
Email: jiejiegroup@126.com
Country: China
ProdList: 4273
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29811
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Wuxi Minglu Medicine technology Co.,Ltd.

Tel: 0510-88726693
Fax: 0510-88726693
Email: 3204601684@qq.com
Country: China
ProdList: 2215
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 10784
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7973
Advantage: 58

Mainchem Co., Ltd.

Tel: --
Fax: --
Email: sarah@mainchem.com
Country: China
ProdList: 6567
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10002
Advantage: 58

Hubei Qifei Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59322506 18071128681
Fax: 027-59322506
Email: 1438082200@qq.com
Country: China
ProdList: 9976
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3006
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-61856358 15229202216
Fax: 029-88380327
Email: 1020@dideu.com
Country: China
ProdList: 10007
Advantage: 58

Wuhan DKY Technology Co.,Ltd.

Tel: 027-81302411 15377658509
Email: zs@dkybpc.com
Country: China
ProdList: 2196
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 8140
Advantage: 58

Yancheng Tongming Biotechnology Co., Ltd.

Tel: 15195160625
Email: 2863565288@qq.com
Country: China
ProdList: 5192
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62163
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9951
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29794
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 15583
Advantage: 58

Hubei Tuobang Chemical Co., Ltd.

Tel: 027-59106185 13986192185
Email: 1466039@qq.com
Country: China
ProdList: 9972
Advantage: 58

Less

View Lastest Price from FLECAINIDE ACETATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Flecainide acetate 54143-56-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Flecainide acetate 54143-56-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: Flecainide acetate 54143-56-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-09

54143-56-5, FLECAINIDE ACETATERelated Search:

Tea tree oil 1-Octadecanol Salicylic acid Dipotassium glycyrrhizinate Benzoic acid Ethanol Acetic acid Glutaraldehyde Sodium benzoate Laurocapram 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid (intermediate of flecainide acetate) FLECAINIDE ACETATE 2-PIPERIDYLMETHYLAMINE Flecainide CHEMBRDG-BB 9071718 N-(piperidin-2-ylmethyl)benzamide 5-HYDROXYFLECAINIDE CHEMBRDG-BB 9070845

2,5-bis-(2,2,2-trifluoroethoxy)-n-(2-piperidinylmethyl)benzamideacetate

n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamidemonoacetate

n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-benzamidmonoacetate

r-818

N-(2-PIPERIDYLMETHYL)-2,5-BIS-(2,2,2-TRIFLUOROETHOXY)BENZAMIDE ACETATE

N-[2-PIPERIDYLMETHYL]-2,5-BIS-[2,2,2-TRIFLUOROETHOXY]BENZAMIDE ACETATE SALT

FLECAINIDE ACETATE

FLECAINIDE ACETATE SALT

FLAC

N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate

N-[2-Pyperidinylmethyl]-2,5-bis[2,2-2-trifluoroethoxy] benzamide acetate

2,5-Bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide acetate

Almarytm

Apocard

Ecrinal

Tambocor

Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetate

Flecainide acetate salt,N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt

Flecainide Acetate (200 mg)

Flecainide-d4 Acetate

Flecainide for system suitability

Flucarney Acetate

N-[[(2S)-2-piperidin-1-iumyl]methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide

Flecainide acetate CRS

Flecainide for system suitability CRS

N-[(RS)-(Piperidin-2-ylmethyl)]-2,5-bis(2,2,2- trifluoroethoxy)benzamide acetate

FLECAINIDE ACETATE USP/EP/BP

Flecainide acetate (F0120000)

Flecainide acetateQ: What is Flecainide acetate Q: What is the CAS Number of Flecainide acetate Q: What is the storage condition of Flecainide acetate Q: What are the applications of Flecainide acetate

Flecainide for system suitability (Y0001274)

Flecainide Acetate (1270800)

Flecainide acetate N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2- trifluoroethoxy)benzamide acetate

N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetate

54143-56-5

54153-56-5

C17H20F6N2O2CH3COOH

C17H20F6N2O3C2H4O2

C17H20F6N2O3C2H4O

C19H24F6N2O5

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Other Sodium Channel Modulators

Sodium Channel Modulators

Voltage-gated Ion Channels

Monovalent Ion Channels

Ion Channels

Organics