FLECAINIDE ACETATE

ChemicalBook > CAS DataBase List > FLECAINIDE ACETATE

Product Name: FLECAINIDE ACETATE
CAS No.: 54143-56-5
Chemical Name: FLECAINIDE ACETATE
Synonyms: FLAC;Apocard;Tambocor;r-818;Ecrinal;Almarytm;Flucarney Acetate;FLECAINIDE ACETATE;Flecainide-d4 Acetate;Flecainide acetate CRS
CBNumber: CB9295801
Molecular Formula: C19H24F6N2O5
Formula Weight: 474.39
MOL File: 54143-56-5.mol

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FLECAINIDE ACETATE Property

Melting point:: 145-147℃
storage temp.: 2-8°C
solubility: Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid.
color: White
Water Solubility: Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water.
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-63
Safety Statements: 22-26-36/37/39-45-46
RIDADR: 3249
WGK Germany: -
RTECS: CV5792550
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F6777
Product name: Flecainide acetate salt
Packaging: 25mg
Price: $166
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2921
Product name: Flecainide Acetate
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $207
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1270800
Product name: Flecainide acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP676
Product name: Flecainide acetate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $259
Updated: 2023/06/20

Alfa Aesar

Product number: J63527
Product name: Flecainide acetate, 98%
Packaging: 100mg
Price: $238
Updated: 2024/03/01

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FLECAINIDE ACETATE Chemical Properties,Usage,Production

Description

Flecainide acetate (54143-56-5) is an open Na+?channel blocker that inhibits fast Na+?current in cardiac muscle in a use- and concentration-dependent manner.1?Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG potassium channels at clinically relevant concentrations.4

Chemical Properties

White or almost white, very hygroscopic, crystalline powder.

Uses

Class I antiarrhythmic.

Uses

Flecainide acetate is used as a sodium channel blocker and as an anti-arrhythmic. In general, it is used to regulate heartbeats of the upper heart and lower heart chambers. It can also be used to slow down an overactive heart. It is also useful in the treatment of ventricular tachycardias and ventricular arrhythmias.

Definition

ChEBI: An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).

brand name

Tambocor (3M Pharmaceuticals).

General Description

Flecainide acetate, N-(2-piperidinylmethyl)-2,5-bis (2,2,2-trifluoroethoxy)benzamide monoacetate(Tambocor), is a class IC antiarrhythmic drug withlocal anesthetic activity; it is a chemical derivative of benzamide.The drug undergoes biotransformation, forming ameta-O-dealkylated compound, whose antiarrhythmic propertiesare half as potent as those of the parent drug, and ameta-O-dealkylated lactam of flecainide with little pharmacologicalactivity. Flecainide acetate is given orally to suppresschronic ventricular ectopy and ventricular tachycardia.It has some limitations because of CNS side effects.

Biological Activity

Open Na + channel blocker that inhibits fast Na + current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.

Biochem/physiol Actions

Class IC antiarrhythmic agent; sodium channel blocker

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: concentration increased by amiodarone - halve dose of flecainide; increased myocardial depression with other anti-arrhythmics.
Antidepressants: concentration increased by fluoxetine; increased risk of ventricular arrhythmias with tricyclics.
Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid.
Antihypertensives: increased myocardial depression and bradycardia with beta-blockers; increased myocardial depression and asystole with verapamil.
Antimalarials: concentration increased by quinine; avoid with artemether/lumefantrine.
Antimuscarinics: increased risk of ventricular arrhythmias with tolterodine.
Antipsychotics: increased risk of ventricular arrhythmias with antipsychotics that prolong the QT interval and phenothiazines; increased risk of arrhythmias with clozapine.
Antivirals: concentration possibly increased by fosamprenavir, indinavir, lopinavir, ritonavir and saquinavir, increased risk of ventricular arrhythmias - avoid; use telaprevir with caution.
Diuretics: increased cardiac toxicity if hypokalaemia occurs.

Metabolism

Flecainide is extensively metabolised (subject to genetic polymorphism), the 2 major metabolites being m-Odealkylated flecainide and m-O-dealkylated lactam of flecainide, both of which may have some activity. Its metabolism appears to involve the cytochrome P450 isoenzyme CYP2D6, which shows genetic polymorphism.
Flecainide is excreted mainly in the urine, approximately 30% as unchanged drug and the remainder as metabolites. About 5% is excreted in the faeces. Haemodialysis removes only about 1% of unchanged flecainide.

storage

Desiccate at +4°C

References

1) Rouet and Ducouret (1994), Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle; J. Cardiovasc. Pharmacol.,?24?177 2) Singh?et al. (1984),?The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions; Ann. N.Y. Acad. Sci.,?432?210 3) Banitt?et al.?(1977),?Anti-arrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides; J. Med. Chem.,?20?821 4) Melgari?et al.?(2015),?Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide; J. Mol. Cell. Cardiol.,?86?42

FLECAINIDE ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FLECAINIDE ACETATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Flecainide Acetate 54143-56-5
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

Dideu Industries Group Limited

Product: FLECAINIDE ACETATE 54143-56-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Flecainide acetate 54143-56-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

54143-56-5, FLECAINIDE ACETATERelated Search:

Tea tree oil 1-Octadecanol Salicylic acid Dipotassium glycyrrhizinate Benzoic acid Ethanol Acetic acid Glutaraldehyde Sodium benzoate Laurocapram 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid (intermediate of flecainide acetate) FLECAINIDE ACETATE 2-PIPERIDYLMETHYLAMINE Flecainide CHEMBRDG-BB 9071718 N-(piperidin-2-ylmethyl)benzamide 5-HYDROXYFLECAINIDE CHEMBRDG-BB 9070845

2,5-bis-(2,2,2-trifluoroethoxy)-n-(2-piperidinylmethyl)benzamideacetate

n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamidemonoacetate

n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-benzamidmonoacetate

r-818

N-(2-PIPERIDYLMETHYL)-2,5-BIS-(2,2,2-TRIFLUOROETHOXY)BENZAMIDE ACETATE

N-[2-PIPERIDYLMETHYL]-2,5-BIS-[2,2,2-TRIFLUOROETHOXY]BENZAMIDE ACETATE SALT

FLECAINIDE ACETATE

FLECAINIDE ACETATE SALT

FLAC

N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate

N-[2-Pyperidinylmethyl]-2,5-bis[2,2-2-trifluoroethoxy] benzamide acetate

2,5-Bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide acetate

Almarytm

Apocard

Ecrinal

Tambocor

Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetate

Flecainide acetate salt,N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt

Flecainide Acetate (200 mg)

Flecainide-d4 Acetate

Flecainide for system suitability

Flucarney Acetate

N-[[(2S)-2-piperidin-1-iumyl]methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide

Flecainide acetate CRS

Flecainide for system suitability CRS

N-[(RS)-(Piperidin-2-ylmethyl)]-2,5-bis(2,2,2- trifluoroethoxy)benzamide acetate

FLECAINIDE ACETATE USP/EP/BP

Flecainide acetate (F0120000)

Flecainide acetateQ: What is Flecainide acetate Q: What is the CAS Number of Flecainide acetate Q: What is the storage condition of Flecainide acetate Q: What are the applications of Flecainide acetate

Flecainide for system suitability (Y0001274)

Flecainide Acetate (1270800)

Flecainide acetate N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2- trifluoroethoxy)benzamide acetate

54143-56-5

54153-56-5

C17H20F6N2O2CH3COOH

C17H20F6N2O3C2H4O2

C17H20F6N2O3C2H4O

C19H24F6N2O5

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