Description Synthesis Applications Notes
ChemicalBook > CAS DataBase List > 4-Aminoacetophenone

4-Aminoacetophenone

Description Synthesis Applications Notes
Product Name
4-Aminoacetophenone
CAS No.
99-92-3
Chemical Name
4-Aminoacetophenone
Synonyms
1-(4-AMINOPHENYL)ETHAN-1-ONE;1-(4-AMINOPHENYL)ETHANONE;P-AMINOACETOPHENONE;4-ACETYLANILINE;p-Acetylaniline;P-AMINOACETYLBENZENE;1-(4-aminophenyl)-ethanon;NSC 3242;usafek-631;USAF EK-631
CBNumber
CB9299995
Molecular Formula
C8H9NO
Formula Weight
135.16
MOL File
99-92-3.mol
More
Less

4-Aminoacetophenone Property

Melting point:
103-107 °C(lit.)
Boiling point:
293 °C(lit.)
Density 
0,77 g/cm
refractive index 
1.5700 (estimate)
Flash point:
292-294°C
storage temp. 
Store below +30°C.
solubility 
6.5g/l
form 
Crystalline Powder
pka
2.17±0.10(Predicted)
Specific Gravity
0.77
color 
Slightly yellow to brown
Water Solubility 
It is soluble in hot water, ethanol and ether.
Merck 
14,413
BRN 
471493
InChIKey
GPRYKVSEZCQIHD-UHFFFAOYSA-N
LogP
0.830
CAS DataBase Reference
99-92-3(CAS DataBase Reference)
NIST Chemistry Reference
Acetophenone, 4'-amino-(99-92-3)
EPA Substance Registry System
4'-Aminoacetophenone (99-92-3)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AM5500000
TSCA 
T
HazardClass 
IRRITANT-HARMFUL
HS Code 
29223900
Hazardous Substances Data
99-92-3(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 381 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A38002
Product name
4′-Aminoacetophenone
Purity
99%
Packaging
25g
Price
$47.8
Updated
2024/03/01
Sigma-Aldrich
Product number
A38002
Product name
4′-Aminoacetophenone
Purity
99%
Packaging
100g
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
A0251
Product name
4'-Aminoacetophenone
Purity
>98.0%(T)
Packaging
25g
Price
$64
Updated
2024/03/01
TCI Chemical
Product number
A0251
Product name
4'-Aminoacetophenone
Purity
>98.0%(T)
Packaging
100g
Price
$190
Updated
2024/03/01
Alfa Aesar
Product number
A13213
Product name
4'-Aminoacetophenone, 99%
Packaging
25g
Price
$26.65
Updated
2024/03/01
More
Less

4-Aminoacetophenone Chemical Properties,Usage,Production

Description

4-Aminoacetophenone is in the form of yellow needle-like crystals, with a melting point of 106°C, a boiling point of 293-295°C, and 195-200°C (2kPa). Soluble in hot water, soluble in alcohol, ether, dilute hydrochloric acid and dilute sulfuric acid, it is slightly soluble in benzene and cold water. Has a special pleasant fragrance. It can be used as a pharmaceutical intermediate.

Applications

4′-Aminoacetophenone, is used in pharmaceuticals, medicines and other organic products. It is also used as a reagent for the photometric determination of Ce. As pharmaceutical intemediate or in the determination of palladium and vitaminB1.

Synthesis

Through a Williamson ether synthesis method and Smiles rearrangement reaction, benzamide compounds are produced, then the 4-aminoacetophenone preparation is finished after hydrolysis. 

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. acids, Incompatible to Acid chlorides, Acid anhydrides, Chloroformates, Strong oxidizing agents, Strong reducing agents. Stable under ordinary conditions.

Chemical Properties

slightly yellow to brown crystalline powder

Uses

4'-Aminoacetophenone, is used in pharmaceuticals, medicines and other organic products. It is also used as a reagent for the photometric determination of Ce. As pharmaceutical intemediate or in the determination of palladium and vitaminB1.

Uses

4-Aminoacetophenone is a novel utilization of aminophenone derivative in toxicology used for treating intoxications with cyanogenic toxic substances.

Uses

4-Aminoacetophenone can be used as an organic reagent to synthesize a variety of organic substances, which is used in the field of anticancer drug preparation and analytical detection. Using it as a raw material, Schiff alkali palladium(II) complexes (cyclopalladiumated compounds) are synthesized by combining metals with carbon atoms. The drug inhibits and kills invasive melanoma cancer cell line (MDA-MB-435)[1]. Hydroxylamine hydrochloride and 4-aminoacetophenone synthesize 4-aminoacetophenone oxime (APO) by oximation reaction, which has a high sensitivity to Organophosphorus (OP)nerve agent mimic-diethylcyanophosphonate. APO can be used to prepare electrochemical sensors with high sensitivity and selectivity to detect OPs[2].

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 2013, 1986 DOI: 10.1248/cpb.34.2013
Tetrahedron Letters, 27, p. 4687, 1986 DOI: 10.1016/S0040-4039(00)85038-8

General Description

4′-Aminoacetophenone, commonly known as Clenbuterol Impurity D, is a related compound of sympathomimetic amine drug clenbuterol. Clenbuterol belongs to a group of compounds referred to as β-2-agonists and is generally used in the treatment of asthma.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO,. See also AROMATIC AMINES

Purification Methods

It is soluble in hot H2O. UV (EtOH) has max 403nm (log 4.42) [Johnson J Am Chem Soc 75 2720 1953]. [Vandenbelt Anal Chem 26 726 1954.] The 2,4-dinitrophenylhydrazone has m 266-267o (from CHCl3 or EtOH) with 403nm (log 4.42), and the max semicarbazone has m 193-194o(dec)(from MeOH). The hydrochloride has m 98o(dec)(from H2O). [Beilstein 14 IV 100.]

Toxicity evaluation

Harmful if swallowed. Causes eye, skin, and respiratory tract irritation. May cause methemoglobinemia.

References

[1] SARTO& L, et al. Anticancer Potential of Palladium(II) Complexes With Schiff Bases Derived from 4-Aminoacetophenone Against Melanoma In Vitro. Anticancer Research, 2019; 39.
[2] Huixiang W, et al. A non-enzymatic electro-chemical sensor for organophosphorus nerve agents mimics and pesticides detections. Organic Electronics, 2017; 252: 1118-1124.

More
Less

4-Aminoacetophenone Suppliers

BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
Garuda Chemicals
Tel
--
Fax
--
Email
manufacturing@garudachem.com
Country
United States
ProdList
70
Advantage
56
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
srlmarketing@dishnetdsl.net
Country
United States
ProdList
1905
Advantage
64
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Naugra Export
Tel
--
Fax
--
Country
United States
ProdList
1332
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Kingchem Inc.
Tel
--
Fax
--
Email
s.wang@kingchem.com
Country
United States
ProdList
757
Advantage
60
Loba Chemie Pvt. Ltd.
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
71
EMD Chemicals Inc.
Tel
--
Fax
--
Email
emdinfo@emdchemicals.com
Country
United States
ProdList
1525
Advantage
77
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Fisher Scientific
Tel
--
Fax
--
Email
sales@fishersci.com
Country
United States
ProdList
2337
Advantage
86
NILE CHEMICALS
Tel
--
Fax
--
Email
nilechem@vsnl.net
Country
United States
ProdList
1369
Advantage
61
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Princeton BioMolecular Research, Inc.
Tel
--
Fax
--
Email
info@princetonbio.com
Country
United States
ProdList
6934
Advantage
51
AB Chem Technologies, LLC
Tel
--
Fax
--
Email
sales@abchemtech.com
Country
United States
ProdList
1101
Advantage
46
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
Eastern Chemical Corp.
Tel
--
Fax
--
Email
eastern@u-g.com
Country
United States
ProdList
2786
Advantage
34
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Richman Chemical Inc.
Tel
--
Fax
--
Email
kac@richmanchemical.com
Country
United States
ProdList
692
Advantage
67
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
More
Less

View Lastest Price from 4-Aminoacetophenone manufacturers

Shanghai Qyubiotech Co., Ltd.
Product
4-Aminoacetophenone 99-92-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%+
Supply Ability
10000kgs per Month
Release date
2023-08-16
Dorne Chemical Technology co. LTD
Product
4-Aminoacetophenone 99-92-3
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 ton
Release date
2024-03-26
Jinan Finer Chemical Co., Ltd
Product
4-Aminoacetophenone 99-92-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300mt
Release date
2021-08-03

99-92-3, 4-AminoacetophenoneRelated Search:


  • 1-(4-aminophenyl)-ethanon
  • 1-(4-aminophenyl)ethanone[qr]
  • 4’-amino-acetophenon
  • 4’-aminoacetophenone[qr]
  • Acetophenone, p-amino-
  • Acetophenone,4’-amino-
  • acetophenone,4-amino-[qr]
  • acetophenone,p-amino-[qr]
  • Ethanone, 1-(4-aminophenyl)-
  • Ethanone,1-(4-aminophenyl)-
  • ethanone,1-(4-aminophenyl)-[qr]
  • Ethanone,l-(4-aminophenyl)-
  • p-Acetylaniline
  • p-acetylaniline[qr]
  • p-Aminoacetofenonu
  • p-amino-acetophenon
  • p-aminoacetophenone[qr]
  • p-aminoacetylbenzene[qr]
  • USAF EK-631
  • p-Aminoacetophenone;P-aminoacetylbenzene;p-Aminophenylmethylketone
  • LABOTEST-BB LTBB000536
  • 4'-Aminoacetophenone 4-Aminoacetophenone
  • P-aminoacetophone
  • 4-AMINOACETOPHENONE STANDARD FOR GC
  • 4-Aminoacetophenone99%
  • 4-AminoaectophenoneForSynthesis
  • 4-Aminoacephenone
  • p-AMINO ACETOPHENONE (4-Amino Acetophenone)
  • 4'-Aminoacetophenone,97%
  • 4-AIMNOACETIPHENONE
  • 1-(4-Aminophenyl)ethan-1-one, 4-Acetylaniline
  • AMINOACETOPHENONE,4-(RG)
  • 4-AMINOAETOPHENONE
  • ρ-Aminoacetylbenzene
  • 4-aminophenylethanone
  • PARA-AMINOACETOPHENONE
  • 4-AMINOACETOPHENONE / 4-ACETYLANILINE
  • p-AMINOACETOPHENONE extrapure AR
  • 1-Acetyl-4-aMinobenzene
  • 4-AcetylphenylaMine
  • NSC 3242
  • 4'-AMINOACETOPHENONE FOR SYNTHESIS
  • 1-(p-aMinophenyl)ethanone
  • 4-aMino-1-acetylbenzene
  • p-aMino-1-acetylbenzene
  • 4-Aminoacetophenone cas 99-92-3 kf-wang(at)kf-chem.com
  • Clenbuterol Impurity 4(Clenbuterol EP Impurity D)
  • Clenbuterol EP Impurity D
  • 1-(4-AMINOPHENYL)ETHANONE
  • 1-(4-AMINOPHENYL)ETHAN-1-ONE
  • usafek-631
  • 4-AMINOPHENYLMETHYL KETONE
  • 4'-AMINOACETOPHENONE
  • 4-AMINOACETOPHENONE
  • 4-ACETYLANILINE
  • AKOS BBS-00003272
  • AMINOACETOPHENONE-4
  • The aMino acetophenone