5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Product Name: 5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
CAS No.: 174672-06-1
Chemical Name: 5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
Synonyms: AN-2718;AN-2718 ，S3532;AN2718, 10 mM in DMSO;5-Chloro-2,1-benzoxaborol-1(3H)-ol;5-chlorobenzo[c][1,2]oxaborol-1(3H)-ol;Inhibitor,AN2718,AN 2718,Fungal,AN-2718,inhibit;5-Chloro-1,3-dihydro-2,1-benzoxaborol-1-ol, 95%;5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole;2,1-Benzoxaborole, 5-chloro-1,3-dihydro-1-hydroxy-
CBNumber: CB93036665
Molecular Formula: C7H6BClO2
Formula Weight: 168.39
MOL File: 174672-06-1.mol

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5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole Property

Melting point:: 150-154 °C
Boiling point:: 273.2±50.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/mL
form: A crystalline solid
pka: 6.60±0.20(Predicted)
color: White to off-white
InChI: InChI=1S/C7H6BClO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
InChIKey: HMAFTPZYFJFEHK-UHFFFAOYSA-N
SMILES: B1(O)C2=CC=C(Cl)C=C2CO1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20708
Product name: AN2718
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 20708
Product name: AN2718
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 20708
Product name: AN2718
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 20708
Product name: AN2718
Purity: ≥98%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

ChemScene

Product number: CS-0019663
Product name: AN2718
Purity: 99.55%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

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5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole Chemical Properties,Usage,Production

Uses

AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.

Biological Activity

AN-2718 inhibits the growth of fungi by inhibiting protein synthesis through the OBORT mechanism.

in vitro

AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus , and from yeasts, C. albicans , with an IC ₅₀ of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T. mentagrophytes .

target

Fungal.

References

[1] Seiradake, et al. Antifungal activity and mechanism of action of a benzoxaborole, AN2718, which is in development for the treatment of tinea pedis. 48th Annual ICAAC/46th Annual IDSA (2008).

5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole Suppliers

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174672-06-1, 5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaboroleRelated Search:

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5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

AN-2718

5-Chloro-1,3-dihydro-2,1-benzoxaborol-1-ol, 95%

5-chlorobenzo[c][1,2]oxaborol-1(3H)-ol

5-Chloro-2,1-benzoxaborol-1(3H)-ol

2,1-Benzoxaborole, 5-chloro-1,3-dihydro-1-hydroxy-

Inhibitor,AN2718,AN 2718,Fungal,AN-2718,inhibit

AN2718, 10 mM in DMSO

AN-2718 ，S3532

174672-06-1

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