ChemicalBook > CAS DataBase List > [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone

Product Name
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
CAS No.
1380548-02-6
Chemical Name
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
Synonyms
SR10067;SR10067, 10 mM in DMSO;REV-ERB Agonist, SR10067;(3-((4-(tert-Butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone;[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone;Methanone, [3-[[4-(1,1-dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenyl-;brain penetrant,inhibit,Rev-Erbβ,REV-ERB,SR 10067,Rev-Erbα,SR10067,neuropsychiatric disorders,SR-10067,metabolic diseases,Inhibitor
CBNumber
CB93039833
Molecular Formula
C31H31NO3
Formula Weight
465.58
MOL File
1380548-02-6.mol
More
Less

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Property

Boiling point:
648.1±50.0 °C(Predicted)
Density 
1.159±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
-2.05±0.40(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Tocris
Product number
6038
Product name
SR10067
Purity
≥98%(HPLC)
Packaging
10
Price
$157
Updated
2021/12/16
Tocris
Product number
6038
Product name
SR10067
Purity
≥98%(HPLC)
Packaging
50
Price
$662
Updated
2021/12/16
TRC
Product number
S684498
Product name
SR10067
Packaging
50mg
Price
$630
Updated
2021/12/16
More
Less

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Chemical Properties,Usage,Production

Uses

SR 10067 is a novel Rev-erbα agonist.

Biological Activity

Cell permeable: yes', 'Primary Target
REV-ERB', 'Reversible: yes', 'Target IC50: 170 nM for REV-ERB&alpha

in vivo

SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse[1].

Animal Model:Mice[1]
Dosage:30 mg/kg
Administration:i.p.
Result:Remained above the IC50 of the receptor in plasma and brain concentrations.
Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity.
Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.

storage

Store at -20°C

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Suppliers

China 26 United Kingdom 1 United States 4 Global 31
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
984
Advantage
58
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2390
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1010
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4798
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
2983
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58

1380548-02-6, [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanoneRelated Search:


  • [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
  • SR10067
  • Methanone, [3-[[4-(1,1-dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenyl-
  • brain penetrant,inhibit,Rev-Erbβ,REV-ERB,SR 10067,Rev-Erbα,SR10067,neuropsychiatric disorders,SR-10067,metabolic diseases,Inhibitor
  • (3-((4-(tert-Butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone
  • SR10067, 10 mM in DMSO
  • REV-ERB Agonist, SR10067
  • 1380548-02-6