tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
- Product Name
- tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
- CAS No.
- 1420859-80-8
- Chemical Name
- tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
- Synonyms
- 1-Boc-3-(2-bromoethyl)azetidine;tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate;3-(2-Bromo-ethyl)-azetidine-1-carboxylic acid tert-butyl ester;1-Azetidinecarboxylic acid, 3-(2-bromoethyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB93052845
- Molecular Formula
- C10H18BrNO2
- Formula Weight
- 264.16
- MOL File
- 1420859-80-8.mol
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Property
- Boiling point:
- 298.1±13.0 °C(Predicted)
- Density
- 1.320±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- -1.68±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C10H18BrNO2/c1-10(2,3)14-9(13)12-6-8(7-12)4-5-11/h8H,4-7H2,1-3H3
- InChIKey
- IMCAWEYWTGJUEH-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC(CCBr)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B997030
- Product name
- tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
- Packaging
- 25mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 0108DV
- Product name
- Tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
- Packaging
- 100mg
- Price
- $856
- Updated
- 2021/12/16
- Product number
- 0108DV
- Product name
- Tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
- Packaging
- 2.5g
- Price
- $2366
- Updated
- 2021/12/16
- Product number
- CM284027
- Product name
- tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $1869
- Updated
- 2021/12/16
- Product number
- CD11260495
- Product name
- tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1980
- Updated
- 2021/12/16
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
152537-03-6
1420859-80-8
General procedure for the synthesis of tert-butyl 3-(2-bromoethyl)azetidine-1-carboxylate from tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate: To a solution of tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate (6.1 g, 30.3 mmol) in dichloromethane (100 mL) was added, in sequence, at 0 °C carbon tetrabromide (19.8 g 60.6 mmol) and triphenylphosphine (15.7 g, 60.6 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=100:1) to afford tert-butyl 3-(2-bromoethyl)azetidine-1-carboxylate (5.5 g, 69.4% yield) as a colorless oil.LC-MS m/z: 208 [M+H-56].
References
[1] Patent: WO2017/27684, 2017, A1. Location in patent: Paragraph 00255
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Suppliers
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