CALPAIN INHIBITOR II

Product Name: CALPAIN INHIBITOR II
CAS No.: 110115-07-6
Chemical Name: CALPAIN INHIBITOR II
Synonyms: ALLM;Calp II;SUAM 312;AC-LLM-CHO;Ac-Leu-Leu-Met-al;AC-LEU-LEU-MET-CHO;CALPAIN INHIBITOR II;AC-LEU-LEU-METHIONINAL;AC-LEU-LEU-MET-ALDEHYDE;AC-LEU-LEU-L-METHIONINAL
CBNumber: CB9305494
Molecular Formula: C19H35N3O4S
Formula Weight: 401.56
MOL File: 110115-07-6.mol

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CALPAIN INHIBITOR II Property

Boiling point:: 676.5±55.0 °C(Predicted)
Density: 1.076±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: ethanol: 20 mg/mL
form: powder
pka: 13.32±0.46(Predicted)
color: white
CAS DataBase Reference: 110115-07-6(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 3-10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A6060
Product name: Calpain Inhibitor II
Purity: powder
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: A6060
Product name: Calpain Inhibitor II
Purity: powder
Packaging: 25mg
Price: $561
Updated: 2024/03/01

Sigma-Aldrich

Product number: 208721
Product name: ALLM - CAS 110115-07-6 - Calbiochem
Packaging: 25mg
Price: $303
Updated: 2024/03/01

Cayman Chemical

Product number: 15994
Product name: Calpain Inhibitor II
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15994
Product name: Calpain Inhibitor II
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

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CALPAIN INHIBITOR II Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Definition

ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide.

General Description

A cell-permeable inhibitor of calpain I (K_i = 120 nM), calpain II (K_i = 230 nM), cathepsin B (K_i = 100 nM), and cathepsin L (K_i = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Biochem/physiol Actions

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

CALPAIN INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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CALPAIN INHIBITOR II Suppliers

China 69 Europe 1 Germany 3 Japan 2 Switzerland 2 United Kingdom 8 United States 21 Global 106

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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Alabiotech Inc.

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View Lastest Price from CALPAIN INHIBITOR II manufacturers

Career Henan Chemical Co

Product: CALPAIN INHIBITOR II 110115-07-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-12

110115-07-6, CALPAIN INHIBITOR IIRelated Search:

Bismuth hydroxide nitrate oxide, BiO5.1 CALPAIN INHIBITOR I Calpain Inhibitor I CALPAIN INHIBITOR II H-TRP-TRP-GLY-TRP-GLY-THR-MET-LEU-LEU-GLY-LEU-LEU-MET-ILE-CYS-OH GTMLLGLLMICSATE H-LEU-GLY-LEU-LEU-MET-ILE-CYS-SER-ALA-THR-GLU-LYS-LEU-TRP-VAL-OH FUSION GLYCOPROTEIN (92-106) [HUMAN RESPIRATORY SYNCYTIAL VIRUS] BIOTINYL-NEUROPEPTIDE W-23 (HUMAN) CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL) H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-SER-GLY-LEU-LEU-MET-GLY-LEU-OH EUKARYOTIC TRANSLATION INITIATION FACTOR 3, SUBUNIT 3 GAMMA (242-250) [HOMO SAPIENS]/[RATTUS NORVEGICUS] H2N-SLLMWITQV-OH ALPHA-1 ANTITRYPSIN FRAGMENT [HOMO SAPIENS]/[PAPIO HAMADRYAS]/[CERCOPITHECUS AETHIOPS] BIOT-PKPPKPVSKMRMATPLLMQA-OH AC-CCLLMPPPPPLFPPPFF-AMIDE CD74 ANTIGEN (INVARIANT POLYPEPTIDE OF MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II ANTIGEN-ASSOCIATED) (98-117) [HOMO SAPIENS] N-ACETYL-LEU-LEU-MET-H

n-acetylleucyl-leucyl-methioninal

Ac-Leu-Leu-Met-al

N-Acetyl-L-Leu-L-Leu-L-Met-OH

Calpain Inhibitor II,96%

CALPAIN INHIBITOR II ;AC-LEU-LEU-MET-CHO

Calp II

SUAM 312

CALPAIN INHIBITOR II

ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONINAL

AC-LLM-CHO

AC-LEU-LEU-L-METHIONINAL

AC-LEU-LEU-MET-ALDEHYDE

AC-LEU-LEU-MET-CHO

AC-LEU-LEU-MET-H (ALDEHYDE)

AC-LEU-LEU-METHIONINAL

ALLM

N-AC-LEU-LEU-METHIONINAL

N-ACETYL-LEU-LEU-MET-CHO

N-ACETYL-LEU-LEU-METHIONINAL

N-ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONAL

N-ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONINAL

L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-

ALLM (Calpain inhibitor II)

110115-07-6

C19H35N3O4S

Biochemicals and Reagents

BioChemical

A to C

Calpain I

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Pepetides

peptides

inhibitor