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CALPAIN INHIBITOR II

Product Name
CALPAIN INHIBITOR II
CAS No.
110115-07-6
Chemical Name
CALPAIN INHIBITOR II
Synonyms
ALLM;Calp II;SUAM 312;AC-LLM-CHO;Ac-Leu-Leu-Met-al;AC-LEU-LEU-MET-CHO;CALPAIN INHIBITOR II;AC-LEU-LEU-METHIONINAL;AC-LEU-LEU-MET-ALDEHYDE;AC-LEU-LEU-L-METHIONINAL
CBNumber
CB9305494
Molecular Formula
C19H35N3O4S
Formula Weight
401.56
MOL File
110115-07-6.mol
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CALPAIN INHIBITOR II Property

Boiling point:
676.5±55.0 °C(Predicted)
Density 
1.076±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
ethanol: 20 mg/mL
form 
powder
pka
13.32±0.46(Predicted)
color 
white
CAS DataBase Reference
110115-07-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
3-10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A6060
Product name
Calpain Inhibitor II
Purity
powder
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
A6060
Product name
Calpain Inhibitor II
Purity
powder
Packaging
25mg
Price
$561
Updated
2024/03/01
Sigma-Aldrich
Product number
208721
Product name
ALLM - CAS 110115-07-6 - Calbiochem
Packaging
25mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
15994
Product name
Calpain Inhibitor II
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15994
Product name
Calpain Inhibitor II
Purity
≥98%
Packaging
5mg
Price
$78
Updated
2024/03/01
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CALPAIN INHIBITOR II Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Definition

ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide.

General Description

A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Biochem/physiol Actions

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

CALPAIN INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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CALPAIN INHIBITOR II Suppliers

China 69 Europe 1 Germany 3 Japan 2 Switzerland 2 United Kingdom 8 United States 21 Global 106
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
995
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59
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
Country
China
ProdList
42982
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
Advantage
60
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View Lastest Price from CALPAIN INHIBITOR II manufacturers

Career Henan Chemical Co
Product
CALPAIN INHIBITOR II 110115-07-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-12

110115-07-6, CALPAIN INHIBITOR IIRelated Search:

Bismuth hydroxide nitrate oxide, BiO5.1 CALPAIN INHIBITOR I Calpain Inhibitor I CALPAIN INHIBITOR II H-TRP-TRP-GLY-TRP-GLY-THR-MET-LEU-LEU-GLY-LEU-LEU-MET-ILE-CYS-OH GTMLLGLLMICSATE H-LEU-GLY-LEU-LEU-MET-ILE-CYS-SER-ALA-THR-GLU-LYS-LEU-TRP-VAL-OH FUSION GLYCOPROTEIN (92-106) [HUMAN RESPIRATORY SYNCYTIAL VIRUS] BIOTINYL-NEUROPEPTIDE W-23 (HUMAN) CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL) H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-SER-GLY-LEU-LEU-MET-GLY-LEU-OH EUKARYOTIC TRANSLATION INITIATION FACTOR 3, SUBUNIT 3 GAMMA (242-250) [HOMO SAPIENS]/[RATTUS NORVEGICUS] H2N-SLLMWITQV-OH ALPHA-1 ANTITRYPSIN FRAGMENT [HOMO SAPIENS]/[PAPIO HAMADRYAS]/[CERCOPITHECUS AETHIOPS] BIOT-PKPPKPVSKMRMATPLLMQA-OH AC-CCLLMPPPPPLFPPPFF-AMIDE CD74 ANTIGEN (INVARIANT POLYPEPTIDE OF MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II ANTIGEN-ASSOCIATED) (98-117) [HOMO SAPIENS] N-ACETYL-LEU-LEU-MET-H

  • n-acetylleucyl-leucyl-methioninal
  • Ac-Leu-Leu-Met-al
  • N-Acetyl-L-Leu-L-Leu-L-Met-OH
  • Calpain Inhibitor II,96%
  • CALPAIN INHIBITOR II ;AC-LEU-LEU-MET-CHO
  • Calp II
  • SUAM 312
  • CALPAIN INHIBITOR II
  • ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONINAL
  • AC-LLM-CHO
  • AC-LEU-LEU-L-METHIONINAL
  • AC-LEU-LEU-MET-ALDEHYDE
  • AC-LEU-LEU-MET-CHO
  • AC-LEU-LEU-MET-H (ALDEHYDE)
  • AC-LEU-LEU-METHIONINAL
  • ALLM
  • N-AC-LEU-LEU-METHIONINAL
  • N-ACETYL-LEU-LEU-MET-CHO
  • N-ACETYL-LEU-LEU-METHIONINAL
  • N-ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONAL
  • N-ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONINAL
  • L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-
  • ALLM (Calpain inhibitor II)
  • 110115-07-6
  • C19H35N3O4S
  • Biochemicals and Reagents
  • BioChemical
  • A to C
  • Calpain I
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • Pepetides
  • peptides
  • inhibitor