CALPAIN INHIBITOR II
- Product Name
- CALPAIN INHIBITOR II
- CAS No.
- 110115-07-6
- Chemical Name
- CALPAIN INHIBITOR II
- Synonyms
- ALLM;Calp II;SUAM 312;AC-LLM-CHO;Ac-Leu-Leu-Met-al;AC-LEU-LEU-MET-CHO;CALPAIN INHIBITOR II;AC-LEU-LEU-METHIONINAL;AC-LEU-LEU-MET-ALDEHYDE;AC-LEU-LEU-L-METHIONINAL
- CBNumber
- CB9305494
- Molecular Formula
- C19H35N3O4S
- Formula Weight
- 401.56
- MOL File
- 110115-07-6.mol
CALPAIN INHIBITOR II Property
- Boiling point:
- 676.5±55.0 °C(Predicted)
- Density
- 1.076±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- ethanol: 20 mg/mL
- form
- powder
- pka
- 13.32±0.46(Predicted)
- color
- white
- CAS DataBase Reference
- 110115-07-6(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- A6060
- Product name
- Calpain Inhibitor II
- Purity
- powder
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- A6060
- Product name
- Calpain Inhibitor II
- Purity
- powder
- Packaging
- 25mg
- Price
- $561
- Updated
- 2024/03/01
- Product number
- 208721
- Product name
- ALLM - CAS 110115-07-6 - Calbiochem
- Packaging
- 25mg
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 15994
- Product name
- Calpain Inhibitor II
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15994
- Product name
- Calpain Inhibitor II
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
CALPAIN INHIBITOR II Chemical Properties,Usage,Production
Chemical Properties
white to off-white powder
Uses
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
Definition
ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide.
General Description
A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Biochem/physiol Actions
Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.
CALPAIN INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
CALPAIN INHIBITOR II Suppliers
View Lastest Price from CALPAIN INHIBITOR II manufacturers
- Product
- CALPAIN INHIBITOR II 110115-07-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-12