2-Cyanophenol

Product Name: 2-Cyanophenol
CAS No.: 611-20-1
Chemical Name: 2-Cyanophenol
Synonyms: 2-HYDROXYBENZONITRILE;CYANOPHENOL;O-CYANOPHENOL;Salicylnitrile;TIMTEC-BB SBB007959;2-Cyanopheno;2-CYANOPHENOL;SALICYLONITRILE;2 /4 CyanoPhenol;2-Cyanophenol,99%
CBNumber: CB9305904
Molecular Formula: C7H5NO
Formula Weight: 119.12
MOL File: 611-20-1.mol

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2-Cyanophenol Property

Melting point:: 92-95 °C (lit.)
Boiling point:: 149 °C/14 mmHg (lit.)
Density: 1.1052
vapor pressure: 0.17Pa at 25℃
refractive index: 1.5372
Flash point:: 149°C/14mm
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Crystalline Powder
pka: 6.86(at 25℃)
color: Off-white to brown
Water Solubility: soluble
BRN: 1210029
Stability:: Stable. Incompatible with strong oxidizing agents, strong bases.
LogP: 1.66 at 30℃
CAS DataBase Reference: 611-20-1(CAS DataBase Reference)
NIST Chemistry Reference: Benzonitrile, 2-hydroxy-(611-20-1)
EPA Substance Registry System: Benzonitrile, 2-hydroxy- (611-20-1)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-45
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29269095

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 141038
Product name: 2-Hydroxybenzonitrile
Purity: 99%
Packaging: 5g
Price: $59.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 141038
Product name: 2-Hydroxybenzonitrile
Purity: 99%
Packaging: 25g
Price: $127
Updated: 2024/03/01

TCI Chemical

Product number: C1045
Product name: 2-Cyanophenol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: C1045
Product name: 2-Cyanophenol
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $120
Updated: 2024/03/01

Alfa Aesar

Product number: A13606
Product name: 2-Hydroxybenzonitrile, 98%
Packaging: 5g
Price: $39.65
Updated: 2024/03/01

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2-Cyanophenol Chemical Properties,Usage,Production

Description

Cyanophenol is a vital molecule widely used to synthesize liquid crystal materials, medicines, spices, pesticides, corrosion inhibitors, etc. Cyanophenol is formed by substituting two hydrogen atoms of benzene molecules with hydroxyl and cyano groups, respectively. The cyano and hydroxyl groups are in the ring plane in the stable molecular structure. The hydroxyl group can have two different orientations relative to the cyano group. 2-cyanophenol, one of the Cyanophenol, is an essential ingredient in pesticides, spices, liquid crystal materials, etc. It is an especially critical intermediate for synthesizing methoxyacrylate fungicide mystrostrobin, widely used in agrochemicals, pharmaceutical chemicals, and other industries. The cyano group can strongly attract electrons. Replacing a hydrogen atom of the benzene ring by the cyano group usually increases the ionization energy (IE)[1].

Chemical Properties

2-Cyanophenol is a white to light yellow crystal powder with a pungent and bitter odor. It is partially soluble in water with a Pka value of 7.17. However, it is unstable when exposed to strong alkalis and oxidants. It is an important intermediate for the synthesis of the fungicide azoxystrobin and the antihypertensive drug Bunirolol.

Uses

2-Hydroxybenzonitrile is used as starting reagent during the synthesis of mono-alkoxyphenyloxazoline, furanoside.

Preparation

A method for preparing 2-cyanophenol, which comprises the following steps: preparing salicylaldoxime; performing dehydration; and performing hydrolytic-acidification reaction, wherein in the dehydration, anhydride is adopted as a dehydrating agent; and in the hydrolytic-acidification reaction, a hydrolyticreagent is 10 to 30 mass percent alkaline solution, and the temperature of the hydrolytic-acidification reaction is 100 to 150℃.

Definition

ChEBI: 2-Cyanophenol is a member of benzenes and a nitrile.

Application

2-Cyanophenol is used in the synthesis of CDK/GSK-3 inhibitors, for usage as therapeutics in Alzheimer's disease (AD).

Flammability and Explosibility

Not classified

Synthesis

2-Hydroxybenzonitrile can be synthesized by condensing salicylaldehyde with hydroxylamine hydrochloride to produce salicylaldoxime. Then, the salicylaldoxime is reacted with acetic anhydride followed by hydrolysis to yield 2-Hydroxybenzonitrile.
Process for the preparation of 2-hydroxybenzonitrile

storage

Store at 2°C - 8°C, close container well, protect from light.

References

[1] Na Li. “Vibrational spectra of 2-cyanophenol cation studied by the mass analyzed threshold ionization technique.” Chemical Physics Letters 792 (2022): Article 139402.

2-Cyanophenol Preparation Products And Raw materials

Raw materials

Salicylaldoxime Salicylaldehyde Hydroxylamine hydrochloride

Preparation Products

ETHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE 2-GLYCIDYLOXYBENZONITRILE 1-(3-AMINO-BENZOFURAN-2-YL)-ETHANONE Bunitrolol 4-Aminosalicylic acid

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View Lastest Price from 2-Cyanophenol manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 2-Cyanophenol 611-20-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-24

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Cyanophenol 611-20-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-19

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Cyanophenol 611-20-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

611-20-1, 2-CyanophenolRelated Search:

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2-Hydroxybenzonitrile, 97+%

2-Cyanophenol SynonyMs: 2-Hydroxybenzonitrile

O-hydroxybanzo nitrile

O-HYDROXYBENZONITRILE

O-CYANOPHENOL

SALICYLIC ACID NITRILE

SALICYLONITRILE

2-CYANOPHENOL (2-HYDROXYBENZONITRILE)

O-HYDROXYBENZONITRIL

2-Cyanophenol, Salicylonitrile

2-Cyanophenol,99%

Benzene, 1-chloro-3-fluoro-2-(trichloromethyl)-

2-Hydroxybenzonitrile ,99%

2-Cyanophenol, 99% 25GR

2-Cyanophenol, 99% 5GR

TIMTEC-BB SBB007959

2-hydroxy-benzonitril

Febuxostat Impurity 107

Benzonitrile, o-hydroxy-

o-Hydoxybenzonitrile

Salicylnitrile

2-HYDROXYBENZONITRILE

2-CYANOPHENOL

2-Hydroxybenzonitrile,98%

Benzonitrile, 2-hydroxy-

2-Hydroxybenzonitrile (o-Hydroxybenzonitrile

CYANOPHENOL

2-Cyanophenol &gt

2-Cyanopheno

Ortho hydroxybenzonitrile

2 /4 CyanoPhenol

2- Hydroxy Benzonitrile ( 2- Cyno Phenol)

611-20-1

611-30-1

NCC6H4OH

HOC6H4CN

C7H5NO

Building Blocks

C6 to C7

Organic Building Blocks

Nitrogen Compounds

Cyanides/Nitriles

Miscellaneous

Imidazoles ,Homopiperidines

Aromatic Nitriles