Chloroacetamido-PEG4-t-Butyl Ester
- Product Name
- Chloroacetamido-PEG4-t-Butyl Ester
- CAS No.
- 1365655-90-8
- Chemical Name
- Chloroacetamido-PEG4-t-Butyl Ester
- Synonyms
- CAS_1365655-90-8;Chloroacetamido-PEG4-C2-Boc;Chloroacetamido-PEG4-t-Butyl Ester;tert-Butyl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate;4,7,10,13-Tetraoxa-16-azaoctadecanoic acid, 18-chloro-17-oxo-, 1,1-dimethylethyl ester
- CBNumber
- CB93062464
- Molecular Formula
- C17H32ClNO7
- Formula Weight
- 397.89
- MOL File
- 1365655-90-8.mol
Chloroacetamido-PEG4-t-Butyl Ester Property
- Boiling point:
- 527.6±50.0 °C(Predicted)
- Density
- 1.119±0.06 g/cm3(Predicted)
- pka
- 13.57±0.46(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C384078
- Product name
- Chloroacetamido-PEG4-t-ButylEster
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BP-20577
- Product name
- Chloroacetamido-PEG4-t-ButylEster
- Purity
- 98%
- Packaging
- 250mg
- Price
- $270
- Updated
- 2021/12/16
- Product number
- BIPG1369
- Product name
- Chloroacetamido-PEG4-t-Butyl Ester
- Packaging
- 250mg
- Price
- $526
- Updated
- 2021/12/16
Chloroacetamido-PEG4-t-Butyl Ester Chemical Properties,Usage,Production
Description
Chloroacetamido-PEG4-t-Butyl Ester is a PEG linker containing a chloroacetamide and a t-butyl ester. The chlorine is a good leaving group and can undergo substitution reactions. The t-butyl group is an acid labile protecting group. Upon removal, the carboxylic acid can be further reacted. The hydrophilic PEG chain increases the water solubilty of compounds in aqueous media.
Uses
Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
IC 50
PEGs; Alkyl/ether
References
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1021/jm2009106
Chloroacetamido-PEG4-t-Butyl Ester Preparation Products And Raw materials
Raw materials
Preparation Products
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