Methoxy-X04
- Product Name
- Methoxy-X04
- CAS No.
- 863918-78-9
- Chemical Name
- Methoxy-X04
- Synonyms
- RMA-333;Methoxy-X04;Methoxy-X04, 10 mM in DMSO;MethoxyX04,Methoxy X04,Methoxy-X-04;Methoxy-X04, amyloid beta fluorescent marker;4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol;4,4'-((1E,1'E)-(2-Methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol;Phenol, 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis- (9CI);4-[(1E)-2-{4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-2-methoxyphenyl}ethenyl]phenol
- CBNumber
- CB93067560
- Molecular Formula
- C23H20O3
- Formula Weight
- 344.4031
- MOL File
- 863918-78-9.mol
Methoxy-X04 Property
- Boiling point:
- 554.2±29.0 °C(Predicted)
- Density
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C,protect from light
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 9.98±0.26(Predicted)
- color
- Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML3861
- Product name
- Methoxy-X04
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $145.35
- Updated
- 2025/07/31
- Product number
- SML3861
- Product name
- Methoxy-X04
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $739
- Updated
- 2025/07/31
- Product number
- 20476
- Product name
- Methoxy-X04
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20476
- Product name
- Methoxy-X04
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 20476
- Product name
- Methoxy-X04
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
Methoxy-X04 Chemical Properties,Usage,Production
Description
Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer''s disease. For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging. Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.
Uses
Methoxy-X04 is a small molecule Aβ-binding agent, which exhibits anti-amyloid effects.
in vivo
Methoxy-X04 (5-10 mg/kg, i.p., once time) differentiates individual plaques in PS1/APP mice within 30 to 60 min[2].
storage
+4°C. Protect from light.
References
[1] WILLIAM E KLUNK. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.[J]. Journal of Neuropathology and Experimental Neurology, 2002, 61 9: 797-805. DOI: 10.1093/jnen/61.9.797
[2] STEFFEN BURGOLD. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks[J]. Acta Neuropathologica, 2010, 121 3: 327-335. DOI: 10.1007/s00401-010-0787-6
Methoxy-X04 Preparation Products And Raw materials
Raw materials
Preparation Products
Methoxy-X04 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77