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Methoxy-X04

Product Name
Methoxy-X04
CAS No.
863918-78-9
Chemical Name
Methoxy-X04
Synonyms
RMA-333;Methoxy-X04;Methoxy-X04, 10 mM in DMSO;MethoxyX04,Methoxy X04,Methoxy-X-04;Methoxy-X04, amyloid beta fluorescent marker;4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol;4,4'-((1E,1'E)-(2-Methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol;Phenol, 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis- (9CI);4-[(1E)-2-{4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-2-methoxyphenyl}ethenyl]phenol
CBNumber
CB93067560
Molecular Formula
C23H20O3
Formula Weight
344.4031
MOL File
863918-78-9.mol
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Methoxy-X04 Property

Boiling point:
554.2±29.0 °C(Predicted)
Density 
1.244±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C,protect from light
solubility 
Soluble in DMSO
form 
crystalline solid
pka
9.98±0.26(Predicted)
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3861
Product name
Methoxy-X04
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$145.35
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3861
Product name
Methoxy-X04
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$739
Updated
2025/07/31
Cayman Chemical
Product number
20476
Product name
Methoxy-X04
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20476
Product name
Methoxy-X04
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
20476
Product name
Methoxy-X04
Purity
≥95%
Packaging
10mg
Price
$169
Updated
2024/03/01
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Methoxy-X04 Chemical Properties,Usage,Production

Description

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer''s disease. For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging. Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.

Uses

Methoxy-X04 is a small molecule Aβ-binding agent, which exhibits anti-amyloid effects.

in vivo

Methoxy-X04 (5-10 mg/kg, i.p., once time) differentiates individual plaques in PS1/APP mice within 30 to 60 min[2].

storage

+4°C. Protect from light.

References

[1] WILLIAM E KLUNK. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.[J]. Journal of Neuropathology and Experimental Neurology, 2002, 61 9: 797-805. DOI: 10.1093/jnen/61.9.797
[2] STEFFEN BURGOLD. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks[J]. Acta Neuropathologica, 2010, 121 3: 327-335. DOI: 10.1007/s00401-010-0787-6

Methoxy-X04 Preparation Products And Raw materials

Raw materials

Preparation Products

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Methoxy-X04 Suppliers

China 74 United Kingdom 2 United States 7 Global 83
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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Aladdin Scientific
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tp@aladdinsci.com
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United States
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57505
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ApexBio Technology
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sales@apexbt.com
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United States
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BOC Sciences
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16314854226
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info@bocsci.com
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United States
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9923
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Abcam Limited
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us.orders@abcam.com
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United States
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Cayman Chemical Company
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
United States Biological
Tel
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80

863918-78-9, Methoxy-X04Related Search:


  • Methoxy-X04
  • 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
  • MethoxyX04,Methoxy X04,Methoxy-X-04
  • Phenol, 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis- (9CI)
  • 4,4'-((1E,1'E)-(2-Methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol
  • 4-[(1E)-2-{4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-2-methoxyphenyl}ethenyl]phenol
  • Methoxy-X04, amyloid beta fluorescent marker
  • Methoxy-X04, 10 mM in DMSO
  • RMA-333
  • 863918-78-9