CREB inhibitor (666-15)

Product Name: CREB inhibitor (666-15)
CAS No.: 1433286-70-4
Chemical Name: CREB inhibitor (666-15)
Synonyms: 666-15;compound3i;CREB 666-15;CREB inhibitor;compound3i(666-15);CREB inhibitor (666-15);breast,666-15,Epigenetic Reader Domain,cancer,CREB,66615,666 15,inhibit,Inhibitor;3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride
CBNumber: CB93069852
Molecular Formula: C33H31Cl2N3O5
Formula Weight: 620.53
MOL File: 1433286-70-4.mol

More

Less

CREB inhibitor (666-15) Property

storage temp.: Store at -20°C
solubility: DMF: 5mg/mL; DMSO: 5mg/mL
form: A solid
Stability:: Hygroscopic

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A616443
Product name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamideHydrochloride
Packaging: 1mg
Price: $95
Updated: 2021/12/16

TRC

Product number: A616443
Product name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamideHydrochloride
Packaging: 5mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-6499
Product name: CREB inhibitor (666-15)
Purity: 99.63%
Packaging: 25mg
Price: $552
Updated: 2021/12/16

ChemScene

Product number: CS-6499
Product name: CREB inhibitor (666-15)
Purity: 99.63%
Packaging: 50mg
Price: $996
Updated: 2021/12/16

ChemScene

Product number: CS-6499
Product name: CREB inhibitor (666-15)
Purity: 99.63%
Packaging: 5mg
Price: $156
Updated: 2021/12/16

More

Less

CREB inhibitor (666-15) Chemical Properties,Usage,Production

Uses

3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide Hydrochloride has been identified as an antitumor agent.

Biological Activity

CREB inhibitor (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM. It also inhibits the growth of cancer cells without affecting normal cells.

in vitro

666-15 can effectively inhibit the growth of cancer cells. In MDA-MB-231 and MDA-MB-468 cells, the GI50 values of 666-15 were 73 nM and 46 nM, respectively. 666-15 also had strong activity in A549 and MCF-7 cells, with GI50 of 0.47 μM and 0.31 μM, respectively. 666-15 inhibits the transcriptional activity of CREB in live cells that do not depend on direct CREB or CBP binding reactions.

in vivo

In the in vivo MDA-MB-468 xenograft tumor model, 666-15 completely inhibited tumor growth without obvious toxicity. Intraperitoneal injection of 10 mg/kg of 666-15 in mice was well tolerated.

target

Target	Value
CREB ()	81 nM

storage

Desiccate at RT

CREB inhibitor (666-15) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CREB inhibitor (666-15) Suppliers

China 44 United States 4 Global 48

Shanghai XingMo Biotechnology Co., Ltd.

Tel: 13524779951
Fax: QQ: 2075692521
Email: 2075692521@qq.com
Country: China
ProdList: 309
Advantage: 55

ATK CHEMICAL COMPANY LIMITED

Tel: 3429815786 13301662590
Fax: +86-21-51619052
Email: sales@atkchemical.com
Country: China
ProdList: 10006
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 879
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

1433286-70-4, CREB inhibitor (666-15)Related Search:

D-RIBULOSE 1,5-DIPHOSPHATE BARIUM*HYDRAT E

CREB inhibitor (666-15)

666-15

compound3i(666-15)

CREB inhibitor

compound3i

CREB 666-15

3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride

breast,666-15,Epigenetic Reader Domain,cancer,CREB,66615,666 15,inhibit,Inhibitor

1433286-70-4