CREB inhibitor (666-15)
- Product Name
- CREB inhibitor (666-15)
- CAS No.
- 1433286-70-4
- Chemical Name
- CREB inhibitor (666-15)
- Synonyms
- 666-15;compound3i;CREB 666-15;CREB inhibitor;compound3i(666-15);CREB inhibitor (666-15);breast,666-15,Epigenetic Reader Domain,cancer,CREB,66615,666 15,inhibit,Inhibitor;3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride
- CBNumber
- CB93069852
- Molecular Formula
- C33H31Cl2N3O5
- Formula Weight
- 620.53
- MOL File
- 1433286-70-4.mol
CREB inhibitor (666-15) Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 5mg/mL; DMSO: 5mg/mL
- form
- A solid
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A616443
- Product name
- 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamideHydrochloride
- Packaging
- 1mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- A616443
- Product name
- 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamideHydrochloride
- Packaging
- 5mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CS-6499
- Product name
- CREB inhibitor (666-15)
- Purity
- 99.63%
- Packaging
- 25mg
- Price
- $552
- Updated
- 2021/12/16
- Product number
- CS-6499
- Product name
- CREB inhibitor (666-15)
- Purity
- 99.63%
- Packaging
- 50mg
- Price
- $996
- Updated
- 2021/12/16
- Product number
- CS-6499
- Product name
- CREB inhibitor (666-15)
- Purity
- 99.63%
- Packaging
- 5mg
- Price
- $156
- Updated
- 2021/12/16
CREB inhibitor (666-15) Chemical Properties,Usage,Production
Uses
3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide Hydrochloride has been identified as an antitumor agent.
Biological Activity
CREB inhibitor (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM. It also inhibits the growth of cancer cells without affecting normal cells.
in vitro
666-15 can effectively inhibit the growth of cancer cells. In MDA-MB-231 and MDA-MB-468 cells, the GI50 values of 666-15 were 73 nM and 46 nM, respectively. 666-15 also had strong activity in A549 and MCF-7 cells, with GI50 of 0.47 μM and 0.31 μM, respectively. 666-15 inhibits the transcriptional activity of CREB in live cells that do not depend on direct CREB or CBP binding reactions.
in vivo
In the in vivo MDA-MB-468 xenograft tumor model, 666-15 completely inhibited tumor growth without obvious toxicity. Intraperitoneal injection of 10 mg/kg of 666-15 in mice was well tolerated.
target
| Target | Value |
| CREB () | 81 nM |
storage
Desiccate at RT
CREB inhibitor (666-15) Preparation Products And Raw materials
Raw materials
Preparation Products
CREB inhibitor (666-15) Suppliers
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