BP-1-102
- Product Name
- BP-1-102
- CAS No.
- 1334493-07-0
- Chemical Name
- BP-1-102
- Synonyms
- BP-1-102;STAT3 Inhibitor XVIII;BP-1-102, 10 mM in DMSO;BP-1-102; BP1-102; BP 1-102.;STAT3 Inhibitor XVIII, BP-1-102;STAT3 INHIBITOR XVIII;BP1-102;BP 1-102;4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydr;4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid;BP-1-102,4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy-
- CBNumber
- CB93069948
- Molecular Formula
- C29H27F5N2O6S
- Formula Weight
- 626.59
- MOL File
- 1334493-07-0.mol
BP-1-102 Property
- Boiling point:
- 749.2±70.0 °C(Predicted)
- Density
- 1.474±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:15.0(Max Conc. mg/mL);23.9(Max Conc. mM)
- form
- A crystalline solid
- pka
- 3.15±0.10(Predicted)
- color
- White to off-white
- InChIKey
- WNVSFFVDMUSXSX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=O)C=C1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 28368
- Product name
- BP-1-102
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 28368
- Product name
- BP-1-102
- Packaging
- 50mg
- Price
- $722
- Updated
- 2024/03/01
- Product number
- 28368
- Product name
- BP-1-102
- Packaging
- 10mg
- Price
- $207
- Updated
- 2024/03/01
- Product number
- 28368
- Product name
- BP-1-102
- Packaging
- 25mg
- Price
- $452
- Updated
- 2024/03/01
- Product number
- B676715
- Product name
- BP1-102
- Packaging
- 10mg
- Price
- $920
- Updated
- 2021/12/16
BP-1-102 Chemical Properties,Usage,Production
Uses
BP-1-102 is a potent and selective STAT3 inhibitor. STAT3 is a cytoplasmic transcription factor that induces the expression of genes related to tumorigenesis. BP 1-102 exhibits antitumor activity against Waldenstrom macroglobulinemia, a rare form of B cell non-Hodgkin lymphoma.
Biological Activity
Primary Target
Stat3
Synthesis
1334493-48-9
1334493-07-0
General method: Benzyl-protected salicylic acid (1 eq.) was dissolved in a stirred solvent mixture of methanol/tetrahydrofuran (1:1, v/v, 0.1 M). After thorough degassing, 10% palladium/carbon catalyst (10 mg/mmol) was cautiously added. The solution was bubbled with hydrogen gas for 5 minutes, followed by continuous stirring of the reaction under hydrogen atmosphere for 3 hours. Upon completion of the reaction, the hydrogen was removed, the palladium catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure.
in vivo
Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas[2]. BP-1-102 is orally bioavailable and that the agent accumulates in tumor tissues at levels sufficient to inhibit aberrantly active Stat3 functions and inhibit tumor growth[1].
IC 50
STAT3: 6.8 μM (IC50)
References
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5605 - 5609
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 11, p. 1102 - 1107
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7190 - 7200
BP-1-102 Preparation Products And Raw materials
Raw materials
Preparation Products
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