ChemicalBook > CAS DataBase List > BP-1-102

BP-1-102

Product Name
BP-1-102
CAS No.
1334493-07-0
Chemical Name
BP-1-102
Synonyms
BP-1-102;STAT3 Inhibitor XVIII;BP-1-102, 10 mM in DMSO;BP-1-102; BP1-102; BP 1-102.;STAT3 Inhibitor XVIII, BP-1-102;STAT3 INHIBITOR XVIII;BP1-102;BP 1-102;4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydr;4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid;BP-1-102,4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy-
CBNumber
CB93069948
Molecular Formula
C29H27F5N2O6S
Formula Weight
626.59
MOL File
1334493-07-0.mol
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BP-1-102 Property

Boiling point:
749.2±70.0 °C(Predicted)
Density 
1.474±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:15.0(Max Conc. mg/mL);23.9(Max Conc. mM)
form 
A crystalline solid
pka
3.15±0.10(Predicted)
color 
White to off-white
InChIKey
WNVSFFVDMUSXSX-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=O)C=C1O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28368
Product name
BP-1-102
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
28368
Product name
BP-1-102
Packaging
50mg
Price
$722
Updated
2024/03/01
Cayman Chemical
Product number
28368
Product name
BP-1-102
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
28368
Product name
BP-1-102
Packaging
25mg
Price
$452
Updated
2024/03/01
TRC
Product number
B676715
Product name
BP1-102
Packaging
10mg
Price
$920
Updated
2021/12/16
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BP-1-102 Chemical Properties,Usage,Production

Uses

BP-1-102 is a potent and selective STAT3 inhibitor. STAT3 is a cytoplasmic transcription factor that induces the expression of genes related to tumorigenesis. BP 1-102 exhibits antitumor activity against Waldenstrom macroglobulinemia, a rare form of B cell non-Hodgkin lymphoma.

Biological Activity

Primary Target
Stat3

Synthesis

1334493-48-9

1334493-07-0

General method: Benzyl-protected salicylic acid (1 eq.) was dissolved in a stirred solvent mixture of methanol/tetrahydrofuran (1:1, v/v, 0.1 M). After thorough degassing, 10% palladium/carbon catalyst (10 mg/mmol) was cautiously added. The solution was bubbled with hydrogen gas for 5 minutes, followed by continuous stirring of the reaction under hydrogen atmosphere for 3 hours. Upon completion of the reaction, the hydrogen was removed, the palladium catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure.

in vivo

Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas[2]. BP-1-102 is orally bioavailable and that the agent accumulates in tumor tissues at levels sufficient to inhibit aberrantly active Stat3 functions and inhibit tumor growth[1].

IC 50

STAT3: 6.8 μM (IC50)

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5605 - 5609
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 11, p. 1102 - 1107
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7190 - 7200

BP-1-102 Preparation Products And Raw materials

Raw materials

Preparation Products

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BP-1-102 Suppliers

China 96 India 2 United States 10 Global 108
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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InvivoChem
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Aladdin Scientific
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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United States Biological
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Cayman Chemical Company
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MedChemExpress
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Matrix Scientific
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1334493-07-0, BP-1-102Related Search:

Epacadostat (INCB024360)

  • BP-1-102
  • 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydr
  • STAT3 Inhibitor XVIII, BP-1-102
  • BP-1-102; BP1-102; BP 1-102.
  • 4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
  • STAT3 Inhibitor XVIII
  • STAT3 INHIBITOR XVIII;BP1-102;BP 1-102
  • Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy-
  • BP-1-102,4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
  • BP-1-102, 10 mM in DMSO
  • 1334493-07-0
  • C29H27F5N2O6S
  • API