1361-50-8 Property

Melting point:

l13-5°C (approx.)

Boiling point:

676.9±55.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

solubility 

Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

12.63±0.70(Predicted)

color 

White to Off-White

Stability:

Hygroscopic

Hazard and Precautionary Statements (GHS)

1361-50-8 Chemical Properties,Usage,Production

Description

A constituent of Taxus baccata, this alkaloid is amorphous and has [α]²⁰_D + 119° (CHC13). The hydrochloride is also amorphous with no definite melting point. The nitrate, however, can be crystallized from Et20-isopropanol, m.p. 190°C. The base yields a diacetyl derivative which, although amorphous when obtained from aqueous solution, m.p. 92°C, forms colourless crystals from EtOH, m.p. 161.5°C. This latter base has [α]²⁰_Do + 106.7° (c 2.0, CHC1 3) and gives a crystalline hydrochloride from EtOH containing solvent of crystallization, m.p. 168-l70°C; nitrate as colourless needles or plates from EtOH, m.p. 141.5°C and the methiodide, m.p. 197°C. The structure of the alkaloid is that of Taxine I (q.v.) minus two acetyl groups.

Uses

Taxine B is a toxic pyrrolizidine alkaloid obtained from rhodadendron and ragwort plants decomposition. An impurity in the biosynthesis of Paclitaxel (P132500)

References

Harrison, Scrowston, Lythgoe., 1. Chern. Soc., C, 1933 (1966)