trans-(4-(trifluoromethyl)cyclohexyl)methanol
Uses- Product Name
- trans-(4-(trifluoromethyl)cyclohexyl)methanol
- CAS No.
- 1202577-61-4
- Chemical Name
- trans-(4-(trifluoromethyl)cyclohexyl)methanol
- Synonyms
- trans-4-(Trifluoromethyl)cyclohexanemethanol;trans-(4-(trifluoromethyl)cyclohexyl)methanol;(1r,4r)-4-(trifluoromethyl)cyclohexyl]methanol;CYCLOHEXANEMETHANOL, 4-(TRIFLUOROMETHYL)-, TRANS-;rel-((1r,4r)-4-(trifluoromethyl)cyclohexyl)methanol
- CBNumber
- CB93102940
- Molecular Formula
- C8H13F3O
- Formula Weight
- 182.18
- MOL File
- 1202577-61-4.mol
trans-(4-(trifluoromethyl)cyclohexyl)methanol Property
- Boiling point:
- 182.2±35.0 °C(Predicted)
- Density
- 1.152±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 15.05±0.10(Predicted)
- form
- liquid
- color
- Colourless
- InChI
- InChI=1S/C8H13F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h6-7,12H,1-5H2/t6-,7-
- InChIKey
- DYUAPKHFRXRMTL-LJGSYFOKSA-N
- SMILES
- [C@@H]1(CO)CC[C@@H](C(F)(F)F)CC1
Safety
- HS Code
- 2906190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C998023
- Product name
- trans-4-(Trifluoromethyl)cyclohexanemethanol
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- PC201052
- Product name
- trans-(4-(Trifluoromethyl)cyclohexyl)methanol
- Packaging
- 100mg
- Price
- $92
- Updated
- 2021/12/16
- Product number
- PC201052
- Product name
- trans-(4-(Trifluoromethyl)cyclohexyl)methanol
- Packaging
- 250mg
- Price
- $148
- Updated
- 2021/12/16
- Product number
- AS58489
- Product name
- trans-4-(trifluoromethyl)cyclohexanemethanol
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- PC201052
- Product name
- trans-(4-(Trifluoromethyl)cyclohexyl)methanol
- Packaging
- 1g
- Price
- $370
- Updated
- 2021/12/16
trans-(4-(trifluoromethyl)cyclohexyl)methanol Chemical Properties,Usage,Production
Uses
trans-(4-(trifluoromethyl)cyclohexyl)methanol is mainly used in organic synthesis and chemical and pharmaceutical research and development.
Synthesis
133261-33-3
1202577-61-4
To a suspension of lithium aluminum hydride (11.6 g, 0.306 mol) in anhydrous tetrahydrofuran (350 mL) was added slowly and dropwise anhydrous tetrahydrofuran solution (50 mL) of trans-4-(trifluoromethyl)cyclohexanecarboxylic acid (30 g, 0.153 mol) at 0 °C. The reaction mixture was stirred continuously at 0°C for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether:ethyl acetate = 10:1) to confirm complete consumption of raw materials. The reaction was quenched sequentially with water (12 mL), 15% aqueous sodium hydroxide solution (24 mL) and water (12 mL). The reaction mixture was filtered and the filtrate was concentrated under reduced pressure to give trans-(4-(trifluoromethyl)cyclohexyl)methanol (24 g, 86% yield) as a colorless liquid. The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 3.49-3.50 (d, J = 6.0 Hz, 2H), 1.91-2.07 (m, 4H), 1.50-1.57 (m, 1H), 1.32-1.36 (m, 2H), 0.98-1.05 (m, 2H).
References
[1] Patent: WO2016/61160, 2016, A1. Location in patent: Paragraph 00172
[2] Patent: US2011/53974, 2011, A1. Location in patent: Page/Page column 54
[3] Patent: WO2014/123882, 2014, A1. Location in patent: Page/Page column 82
[4] Patent: WO2017/24018, 2017, A1. Location in patent: Paragraph 00159; 00160
trans-(4-(trifluoromethyl)cyclohexyl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from trans-(4-(trifluoromethyl)cyclohexyl)methanol manufacturers
- Product
- Trans-(4-(trifluoromethyl)cyclohexyl)methanol 1202577-61-4
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-24