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(R)-(+)-1-(4-Methylphenyl)ethylamine

Product Name
(R)-(+)-1-(4-Methylphenyl)ethylamine
CAS No.
4187-38-6
Chemical Name
(R)-(+)-1-(4-Methylphenyl)ethylamine
Synonyms
Tolylethylamine;(R)-1-P-TOLYLETHANAMINE;Methyl phenyl-ethylamine;(+)-p,α-Dimethylbenzylamine;alpha,4-dimethylbenzylamine;(R)-1-(p-tolyl)ethan-1-amine;(R)-(+)-1-(P-TOLYL)ETHYLAMINE;(R)-(+)-A-(P-TOLYL)ETHYLAMINE;(R)-(+)-4-(1-AMINOETHYL)TOLUENE;(R)-alpha,p-Dimethylbenzylamine
CBNumber
CB9311444
Molecular Formula
C9H13N
Formula Weight
135.21
MOL File
4187-38-6.mol
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(R)-(+)-1-(4-Methylphenyl)ethylamine Property

Melting point:
<-20°C
Boiling point:
205 °C (lit.)
alpha 
37 º (NEAT)
Density 
0.919 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.521(lit.)
Flash point:
180 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
9.20±0.10(Predicted)
Specific Gravity
0.919
optical activity
[α]20/D +37°, neat
Sensitive 
Air Sensitive
BRN 
3195425
CAS DataBase Reference
4187-38-6(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
20/21/22-34
Safety Statements 
16-26-27-36/37/39-45
RIDADR 
UN 2619 8/PG 2
WGK Germany 
3
HazardClass 
8
PackingGroup 
III
HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
726664
Product name
(R)-(+)-α,4-Dimethylbenzylamine
Purity
ChiPros
Packaging
5g
Price
$104
Updated
2024/03/01
Sigma-Aldrich
Product number
405248
Product name
(R)-(+)-α,4-Dimethylbenzylamine
Purity
98%
Packaging
1g
Price
$122
Updated
2023/06/20
TCI Chemical
Product number
T1380
Product name
(R)-(+)-1-(p-Tolyl)ethylamine
Purity
>98.0%(GC)
Packaging
1mL
Price
$99
Updated
2021/12/16
Alfa Aesar
Product number
L16328
Product name
(R)-(+)-1-(4-Methylphenyl)ethylamine, ChiPros 98+%
Purity
ee 98%
Packaging
5g
Price
$71
Updated
2021/12/16
Alfa Aesar
Product number
L16328
Product name
(R)-(+)-1-(4-Methylphenyl)ethylamine, ChiPros 98+%
Purity
ee 98%
Packaging
1g
Price
$34.9
Updated
2021/12/16
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(R)-(+)-1-(4-Methylphenyl)ethylamine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid

Uses

(R)-(+)-α,4-Dimethylbenzylamine can be used as a chiral salt of keto acid, employed in the solid-state photolysis studies of α-mesitylacetophenone derivatives.

Application

(R)-(+)-α,4-Dimethylbenzylamine reacts with 1,5-difluoro-2,4-dinitrobenzene (DFDNB) to form a chiral derivative reagent(CDR) via substitution of one fluorine atom.

General Description

(R)-(+)-α,4-Dimethylbenzylamine is a chiral amine.

Synthesis

(R)-(+)-1-(4-methylphenyl)ethylamine was synthesized via a series of chemical reactions with (R)-N-[1-(4-methylphenyl)ethyl]acetamide. The steps are as follows:
1 g of the compound obtained in the previous stage will be used. 2 g of n-butanol was added, 0.63 g of potassium hydroxide was added, and the temperature was raised to 100 ° C. After 24 hours of heat preservation, cool down to 10 to 20 ℃. After adding water and stirring for 0.5 hours, the mixture was allowed to stand for separation, and the organic layer was concentrated to n-butanol, and then subjected to vacuum distillation (80-100 ℃ packed column) to obtain (R)-1-(4-methylphenyl)ethylamine 0.63 g. The yield was 82%, the HPLC purity was 96.3%, and the enantiomer was 0.8%.

structure and hydrogen bonding

(R)-(+)-1-(4-Methylphenyl)ethylamine is a chiral molecule studied in the context of crystallographic analysis and optimization. Through X-ray diffraction analysis, the crystal structure of (R)-(+)-1-(4-Methylphenyl)ethylamine was determined, revealing the presence of a significant hydrogen bond between the amine group and one of the carbonyl groups. This hydrogen bond plays a crucial role in stabilizing the (R)-(+)-1-(4-Methylphenyl)ethylamine molecule, which is a recurring pattern observed in structurally similar compounds. Furthermore, the (S)-(+)-enantiomer of (R)-(+)-1-(4-Methylphenyl)ethylamine was synthesized using an enantiopure precursor, establishing an efficient method to obtain this desired form of the molecule.

(R)-(+)-1-(4-Methylphenyl)ethylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-1-(4-Methylphenyl)ethylamine Suppliers

China 95 Europe 1 France 2 Germany 6 India 8 Italy 1 Japan 3 Slovakia 1 Switzerland 2 United Kingdom 8 United States 19 Global 146
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View Lastest Price from (R)-(+)-1-(4-Methylphenyl)ethylamine manufacturers

Career Henan Chemical Co
Product
(R)-(+)-1-(4-Methylphenyl)ethylamine 4187-38-6
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-12

4187-38-6, (R)-(+)-1-(4-Methylphenyl)ethylamineRelated Search:

Ethylamine Dichloromethylphenylsilane Methyltriphenylphosphonium bromide Trimethylphenylammonium chloride Diethylamine Triethylamine Diethylstilbestrol (S)-(+)-N-(3,5-DINITROBENZOYL)-ALPHA-PHENYLETHYLAMINE 2-Amino-2-phenylacetic acid N-METHYL-D-ALANINE N-Benzylethanolamine N-BENZOYL-DL-ALANINE Hippuric acid Dibenzylamine DL-2-Phenylglycinol (S)-(-)-N,ALPHA-DIMETHYLBENZYLAMINE L-1-Phenylethylamine Phenylacetone

  • (R)-alpha,p-Dimethylbenzylamine
  • Tolylethylamine
  • Methyl phenyl-ethylamine
  • (R)-(+)-4-(1-AMINOETHYL)TOLUENE
  • (R)-4-METHYL-ALPHA-METHYLBENZYLAMINE
  • (R)-(+)-ALPHA,4-DIMETHYLBENZYLAMINE
  • (R)-(+)-A-(P-TOLYL)ETHYLAMINE
  • (R)-(+)-1-(4-METHYLPHENYL)ETHYLAMINE
  • (R)-1-(4-METHYLPHENYL)ETHYLAMINE
  • (R)-1-P-TOLYLETHANAMINE
  • (R)-(+)-1-(P-TOLYL)ETHYLAMINE
  • Benzenemethanamine, .alpha.,4-dimethyl-, (.alpha.R)-
  • (R)-1-(4-METHYLPHENYL)ETHYLAMINE-HCl
  • (+)-p,α-Dimethylbenzylamine
  • (αR)-α,4-Dimethylbenzenemethanamine
  • [R,(+)]-p,α-Dimethylbenzylamine
  • (R)-(+)-ALPHA,4-DIMETHYLBENZYLAMINE, 98+ % (98% EE/GLC)
  • (R)-(+)-α,4-DIMETHYLBENZYLAMINE
  • (R)-(+)-1-(4-METHYLPHENYL)ETHYLAMINE , EE 98%
  • (R)-(+)-1-(P-TOLYL)ETHYLAMINE 98+%
  • (R)-(+)-1-(4-METHYLPHENYL)ETHYLAMINE, CHIPROS 98+%, EE 98%
  • Benzenemethanamine, α,4-dimethyl-, (αR)-
  • alpha,4-dimethylbenzylamine
  • (<i>R</i>)-(+)-1-(<i>p</i>-Tolyl)ethylamine
  • (R)-1-(p-tolyl)ethan-1-amine
  • (1R)-1-(4-methylphenyl)ethanamine
  • (1R)-(+)-1-(4-Methylphenyl)ethylamine
  • (R)-(+)-α,4-Dimethylbenzylamine
  • (R)-(+)-(4-Methylphenyl)ehtylamine
  • 4187-38-6
  • Amines
  • Organic Building Blocks
  • Optical Resolution
  • Chiral Building Blocks
  • for Resolution of Acids
  • Amines (Chiral)
  • Asymmetric Synthesis
  • Amines
  • Chiral Building Blocks
  • Organic Building Blocks
  • chiral
  • API intermediates
  • Amines (Chiral)
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • for Resolution of Acids
  • Optical Resolution
  • Synthetic Organic Chemistry