ChemicalBook > CAS DataBase List > Oxytetracycline hydrochloride

Oxytetracycline hydrochloride

Product Name
Oxytetracycline hydrochloride
CAS No.
2058-46-0
Chemical Name
Oxytetracycline hydrochloride
Synonyms
OXYTETRACYCLINE HCL;OTC;TETRAMYCIN;AQUACYCLINE;Oxyteracycline HCL;[4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride;tm5;nsc9169;mepatar;TOXINAL
CBNumber
CB9311671
Molecular Formula
C22H25ClN2O9
Formula Weight
496.89
MOL File
2058-46-0.mol
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Oxytetracycline hydrochloride Property

Melting point:
180°C
alpha 
-188～-200°(D/20℃)(c=1,0.1mol/l HCl) (calculated on the dried basis)
storage temp. 
0-6°C
solubility 
Freely soluble in water, sparingly soluble in ethanol (96 per cent). Solutions in water become turbid on standing, owing to the precipitation of oxytetracycline.
form 
crystalline
color 
yellow
PH
2.0～3.0 (10g/l, 25℃)
Water Solubility 
>100 g/L
Sensitive 
Light Sensitive
λmax
360nm(H2O)(lit.)
Merck 
14,6976
BRN 
3853107
Stability:
Hygroscopic
CAS DataBase Reference
2058-46-0(CAS DataBase Reference)
EPA Substance Registry System
Oxytetracycline hydrochloride (2058-46-0)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
63
Safety Statements 
45-53-36/37/39
WGK Germany 
2
RTECS 
QI8225000
F 
8-10-23
TSCA 
Yes
HS Code 
29413000
Toxicity
LD50 oral in mouse: 6696mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O5875
Product name
Oxytetracycline hydrochloride
Purity
≥95% (HPLC), crystalline
Packaging
10g
Price
$70
Updated
2024/03/01
Sigma-Aldrich
Product number
1491015
Product name
Oxytetracycline hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
O0475
Product name
Oxytetracycline Hydrochloride
Purity
>95.0%(HPLC)(T)
Packaging
5g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
O0475
Product name
Oxytetracycline Hydrochloride
Purity
>95.0%(HPLC)(T)
Packaging
25g
Price
$95
Updated
2024/03/01
Alfa Aesar
Product number
J62489
Product name
Oxytetracycline hydrochloride
Packaging
25g
Price
$92.5
Updated
2024/03/01
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Oxytetracycline hydrochloride Chemical Properties,Usage,Production

Description

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells and antibiotic susceptibilities of Mycoplasma bovis isolates.

Chemical Properties

Yellow Crystalline Solid

Originator

Terramycin,Pfizer,US,1950

Uses

Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Uses

Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial

Uses

Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome- lysosome (P-L) fusion in P388D1 cells1 and antibiotic susceptibilities of Mycoplasma bovis isolates.

Definition

ChEBI: Oxytetracycline hydrochloride is an organic molecular entity.

Manufacturing Process

The pH was adjusted to 7.0 with sodium hydroxide and calcium carbonate was added at the rate of 1 g/l.
500 ml portions of the above medium were added to Fernbach flasks which were then sterilized at 121°C for 30 minutes. Upon cooling, the flasks were inoculated with a suspension of the growth of s. rimosus obtained from the surface of beef lactose agar slants, and the flasks were shaken for 4 days at 28°C on a rotary shaker having a displacement of 2" at an rpm of 200. At the end of this period the broth was found to contain 640 C.D.U/ml and 400 chloramphenicol units/ml. The mycelium was separated from the broth by filtration and the latter was adjusted to pH 9.0. The antibiotic was extracted from the broth with n-butanol, and when the ultraviolet absorption spectrum was observed on the butanol solution of the antibiotic, peaks in the absorption curve were found at 385 and 270 millimicrons.

brand name

Terramycin (Pfizer).

Therapeutic Function

Antibiotic

General Description

Oxytetracycline hydrochloride appears as odorless fluffy yellow solid or yellow powder. Bitter taste. (NTP, 1992)

General Description

Early in 1950, Finlay et al.182 reported the isolation of oxytetracycline(Terramycin) from S. rimosus. This compoundwas soon identified as a chemical analog of chlortetracycline that showed similar antibiotic properties. The structureof oxytetracycline was elucidated by Hochstein et al.183 andthis work provided the basis for the confirmation of thestructure of the other tetracyclines.
Oxytetracycline hydrochloride is a pale yellow, bitter,crystalline compound. The amphoteric base is only slightlysoluble in water and slightly soluble in alcohol. It is odorlessand stable in air but darkens on exposure to strong sunlight.The hydrochloride salt is a stable yellow powder that ismore bitter than the free base. It is much more soluble inwater, 1 g dissolving in 2 mL, and more soluble in alcoholthan the free base. Both compounds are inactivated rapidlyby alkali hydroxides and by acid solutions below pH 2. Bothforms of oxytetracycline are absorbed rapidly and equallywell from the digestive tract, so the only real advantage thefree base offers over the hydrochloride salt is that it is lessbitter. Oxytetracycline hydrochloride is also used for parenteraladministration (intravenously and intramuscularly).

Air & Water Reactions

Oxytetracycline hydrochloride is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing.

Reactivity Profile

Oxytetracycline hydrochloride is sensitive to light. Oxytetracycline hydrochloride may be unstable at temperatures above 77° F. Oxytetracycline hydrochloride darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. Oxytetracycline hydrochloride undergoes hydrolysis in the presence of water. Oxytetracycline hydrochloride may be incompatible with alkalis.

Fire Hazard

Flash point data for Oxytetracycline hydrochloride are not available. Oxytetracycline hydrochloride is probably combustible.

Oxytetracycline hydrochloride Preparation Products And Raw materials

Raw materials

Oxytetracycline Hydrochloric acid Methanol Activated carbon Sulfuric acid

Preparation Products

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Oxytetracycline hydrochloride Suppliers

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View Lastest Price from Oxytetracycline hydrochloride manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.
Product
Oxytetracycline Hydrochloride 2058-46-0
Price
US $0.00/kg
Min. Order
25kg
Purity
≥835ug/mg
Supply Ability
10tons
Release date
2024-04-24
Hebei Longbang Technology Co., Ltd
Product
Oxytetracycline hydrochloride 2058-46-0
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-05-24
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Oxytetracycline HCl 2058-46-0
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-07

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