ABT-639
- Product Name
- ABT-639
- CAS No.
- 1235560-28-7
- Chemical Name
- ABT-639
- Synonyms
- ABT-639;ABT-693;CS-2286;ABT-639 (ABT639;ABT-639, CID 46851313;Calcium Channel,Ca channels,Ca2+ channels,inhibit,Inhibitor,ABT639,ABT-639;(R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide;4-CHLORO-2-FLURO-N-(2-FLUOROPHENYL)-5-[(8AR)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-2(1H)-YLCARBONYL]BENZENESULFONAMIDE;4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide;Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-
- CBNumber
- CB93121075
- Molecular Formula
- C20H20ClF2N3O3S
- Formula Weight
- 455.91
- MOL File
- 1235560-28-7.mol
ABT-639 Property
- Boiling point:
- 612.2±65.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:9.71(Max Conc. mg/mL);21.3(Max Conc. mM)
DMF:14.0(Max Conc. mg/mL);30.71(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.09(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.1(Max Conc. mM) - form
- A solid
- pka
- 6.80±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 28742
- Product name
- ABT-639
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 28742
- Product name
- ABT-639
- Packaging
- 25mg
- Price
- $586
- Updated
- 2024/03/01
- Product number
- 28742
- Product name
- ABT-639
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 28742
- Product name
- ABT-639
- Packaging
- 10mg
- Price
- $257
- Updated
- 2024/03/01
- Product number
- 6770
- Product name
- ABT639
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $220
- Updated
- 2021/12/16
ABT-639 Chemical Properties,Usage,Production
Description
ABT-639 is a T-type calcium channel blocker. It inhibits inactivated-state Cav3.2 channels with an IC50 value of 2.3 μM and inactivated-state Cav3.1 and Cav3.3 channels by 50 and 39%, respectively, when used at a concentration of 10 μM. ABT-639 selectively inhibits inactivated-state T-type calcium currents over resting-state currents in rat dorsal root ganglion (DRG) neurons (IC50s = 7.6 and >30 μM, respectively). It reverses the hind limb grip force deficit in a rat model of osteoarthritic pain induced by monoiodoacetic acid (MIA; ED50 = 2 mg/kg). ABT-639 also increases the paw withdrawal threshold in rat spinal nerve ligation (SNL) and chronic constriction injury (CCI) models of neuropathic pain in a dose-dependent manner and attenuates cold allodynia in the CCI rat model when administered at doses greater than or equal to 3 mg/kg.
Description
ABT-639 is a selective T-type calcium channel blocker with efficacy in a wide range of preclinical models of nociceptive and neuropathic pain.ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.
storage
Store at -20°C
References
Zhang, Q., et al. "Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639."Acs Medicinal Chemistry Letters6.6(2015):150429091057009.
Serra, J, et al. "Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. " Pain 156.11(2015):2175.
http://www.medkoo.com/products/6989
ABT-639 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ABT-639 manufacturers
- Product
- 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]benzenesulfonamide 1235560-28-7
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- Min98% HPLC
- Supply Ability
- g/kg /ton
- Release date
- 2019-12-20