AS1842856
- Product Name
- AS1842856
- CAS No.
- 836620-48-5
- Chemical Name
- AS1842856
- Synonyms
- CS-2538;AS1842856;AS 1842856;AS-1842856;5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-
- CBNumber
- CB93122441
- Molecular Formula
- C18H22FN3O3
- Formula Weight
- 347.38
- MOL File
- 836620-48-5.mol
AS1842856 Property
- Boiling point:
- 587.3±50.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:5.0(Max Conc. mg/mL);14.39(Max Conc. mM)
- form
- A crystalline solid
- pka
- 6.47±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16761
- Product name
- AS-1842856
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2024/03/01
- Product number
- 16761
- Product name
- AS-1842856
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 16761
- Product name
- AS-1842856
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 4265
- Product name
- AS1842856
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $95
- Updated
- 2021/12/16
- Product number
- A790073
- Product name
- AS1842856
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
AS1842856 Chemical Properties,Usage,Production
Description
AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells). Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.,
Uses
AS 1842856 is a novel FoxO1 antagonist with anti-obesity effects.
Definition
ChEBI: AS1842856 is a quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. It has a role as a hypoglycemic agent, an anti-obesity agent, an autophagy inhibitor, an antineoplastic agent, an apoptosis inducer and a forkhead box protein O1 inhibitor. It is a quinolinemonocarboxylic acid, a quinolone, an organofluorine compound, a primary amino compound, a secondary amino compound and a tertiary amino compound.
storage
Store at -20°C
AS1842856 Preparation Products And Raw materials
Raw materials
Preparation Products
AS1842856 Suppliers
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View Lastest Price from AS1842856 manufacturers
- Product
- AS1842856 836620-48-5
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09