AZ6102

Product Name: AZ6102
CAS No.: 1645286-75-4
Chemical Name: AZ6102
Synonyms: AZ6102;CS-2332;AZ6102 >=98% (HPLC);AZ-6102;AZ6102;AZ 6102;AZ 6102,PARP,AZ-6102,Inhibitor,poly ADP ribose polymerase,inhibit,AZ6102;2-(4-(6-(cis-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one;2-(4-(6-((3S,5R)-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3Hpyrrolo[2,3-d]pyrimidin-4(7H)-one;rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-, rel-
CBNumber: CB93126696
Molecular Formula: C25H28N6O
Formula Weight: 428.53
MOL File: 1645286-75-4.mol

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AZ6102 Property

Boiling point:: 657.6±65.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 8.70±0.60(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19898
Product name: AZ 6102
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19898
Product name: AZ 6102
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 19898
Product name: AZ 6102
Purity: ≥98%
Packaging: 10mg
Price: $231
Updated: 2024/03/01

Cayman Chemical

Product number: 19898
Product name: AZ 6102
Purity: ≥98%
Packaging: 25mg
Price: $530
Updated: 2024/03/01

Tocris

Product number: 5775
Product name: AZ6102
Purity: ≥98%(HPLC)
Packaging: 50
Price: $924
Updated: 2021/12/16

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AZ6102 Chemical Properties,Usage,Production

Uses

AZ 6102 is a a potent TNKS1/2 inhibitor that has 100-fold selectivity against other poly(ADP-ribose) polymerase (PARP) family enzymes.

Biological Activity

az6102 is a tnks1/2 inhibitor.inhibition of the poly(adp-ribose) polymerase (parp) catalytic domain of the tankyrases (tnks1 and tnks2) is reported to inhibit the wnt pathway by increasing stabilization of axin. the canonical wnt pathway plays a critical role in adult tissue homeostasis, embryonic development, as well as cancer.

in vitro

az6102 was identified as a potent tnks1/2 inhibitor with 100-fold selectivity against other parp family enzymes including parps 1, 2, and 6. in addition, az6102 showed a 5 nm ic50 against wnt pathway in dld-1 cells [1].

in vivo

in animal study, az6102 was intravenously dosed to nude mice at 25 mg/kg, and the results showed that az6102 had a clearance of 24 ml/min·kg and a half-life of 4 h. the bioavailability of az6102 in mouse and rat was only moderate at 12% and 18%, respectively. in addition, az6102 was used as an intravenous probe compound to evaluate the in vivo effects of tnks1/2 inhibition on normal tissue and tumor xenografts, however, the results of such experiments have not be released so far [1].

IC 50

1 and 3 nm for tnks2 and tnks1, respectively

storage

Store at -20°C

References

[1] j. w. johannes, l. almeida, b. barlaam,et al.pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathways inhibitors suitable for in vivopharmacology. acs med. chem. lett. 6, 254-259 (2015).

AZ6102 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ6102 Suppliers

China 64 United Kingdom 1 United States 11 Global 76

Musechem

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Aladdin Scientific

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MedChemExpress

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View Lastest Price from AZ6102 manufacturers

PNP Biotech Co. Ltd

Product: AZ6102 1645286-75-4
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-09-16

1645286-75-4, AZ6102Related Search:

AZ-6102;AZ6102;AZ 6102

CS-2332

AZ6102

rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one

4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-, rel-

AZ6102 >=98% (HPLC)

2-(4-(6-((3S,5R)-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3Hpyrrolo[2,3-d]pyrimidin-4(7H)-one

AZ 6102,PARP,AZ-6102,Inhibitor,poly ADP ribose polymerase,inhibit,AZ6102

2-(4-(6-(cis-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

1645286-75-4