MBP146-78
- Product Name
- MBP146-78
- CAS No.
- 188343-77-3
- Chemical Name
- MBP146-78
- Synonyms
- CS-2661;MBP146-78;MBP146-78;MBP146-78;MBP146-78, 10 mM in DMSO;Parasite,MBP-146-78,MBP146-78,MBP146 78,inhibit,MBP14678,Inhibitor;4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine;4-[2-(4-Fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]pyridine;Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-;4-(2-(4-Fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl)pyridine , MBP146-78
- CBNumber
- CB93133421
- Molecular Formula
- C21H22FN3
- Formula Weight
- 335.42
- MOL File
- 188343-77-3.mol
MBP146-78 Property
- Boiling point:
- 477.6±45.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 7.69 mg/mL (22.93 mM)
- pka
- 16.04±0.50(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-6482
- Product name
- MBP146-78
- Purity
- 99.91%
- Packaging
- 1mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- SYN1227
- Product name
- MBP146-78
- Packaging
- 1mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-6482
- Product name
- MBP146-78
- Purity
- 99.91%
- Packaging
- 5mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- SYN-1227-M010
- Product name
- MBP146-78
- Purity
- ≥95%(HPLC)
- Packaging
- 10mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- CS-6482
- Product name
- MBP146-78
- Purity
- 99.91%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
MBP146-78 Chemical Properties,Usage,Production
Uses
MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.
Biological Activity
MBP146-78 is a potent and selective cyclic GMP(cGMP)-dependent protein kinases/Protein Kinase G (PKG) inhibitor that exhibits cytostatic activity against Toxoplasma gondii.
in vitro
MBP146-78 displays a dose-dependent inhibition of T. gondii tachyzoites replicating inside HFFs, with an IC 50 of 210 nM. The suppression of lytic parasite growth by MBP146-78 is reversible. Replacement of the medium with medium lacking MBP146-78, after treatment for up to 7 days at 2 μM, results in complete lysis of HFF cell monolayers. MBP146-78 is neither toxic nor inhibitory to proliferating or confluent monolayers of HFFs at concentrations of up to 10 μM.
in vivo
In infected mice that are treated with MBP146-78 at 50 mg/kg twice daily, parasites are undetectable throughout the 10-day treatment period in each of the tissues examined. However, samples from brain, spleen, and lung taken from infected treated mice reveal the presence of parasites after cessation of administration of MBP146-78, indicating that a transient asymptomatic parasite recrudescence occurs in all survivors. The ability of mice to control Toxoplasma infection after MBP146-78 treatment has been terminated suggests that the mouse immune system plays a synergistic role with chemotherapy in controlling the infection.
target
| Target | Value |
| PKG () |