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CCT196969

Product Name
CCT196969
CAS No.
1163719-56-9
Chemical Name
CCT196969
Synonyms
CS-2447;CCT196969;CCT196969 ，S7743;CCT196969 (CCT-196969;CCT196969, 10 mM in DMSO;CCT196969; CCT-196969; CCT 196969;CCT 196969,Raf,CCT196969,CCT-196969,Inhibitor,inhibit,Raf kinases;1-(3-(tert-Butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyra;Urea, N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-
CBNumber
CB93134226
Molecular Formula
C27H24FN7O3
Formula Weight
513.52
MOL File
1163719-56-9.mol
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CCT196969 Property

storage temp. 
Store at -20°C
solubility 
DMSO: Soluble
form 
A solid
color 
White to off-white
InChIKey
KYYKGSDLXXKQCR-UHFFFAOYSA-N
SMILES
N(C1=CC=C(OC2=C3N=CC(=O)NC3=NC=C2)C=C1F)C(NC1N(C2=CC=CC=C2)N=C(C(C)(C)C)C=1)=O
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25537
Product name
CCT196969
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
25537
Product name
CCT196969
Purity
≥95%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
25537
Product name
CCT196969
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
25537
Product name
CCT196969
Purity
≥95%
Packaging
25mg
Price
$343
Updated
2024/03/01
TRC
Product number
C227940
Product name
CCT196969
Packaging
10mg
Price
$160
Updated
2021/12/16
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CCT196969 Chemical Properties,Usage,Production

Uses

CCT196969 is a paradox-breaking RAF inhibitor that also targets SRC and is thus effective in drug-resistant BRAF mutant melanoma.

in vivo

CCT196969 is extremely well tolerated and does not produce any significant adverse effects in vivo. It inhibits the growth of NRAS mutant DO4 tumor xenografts in nude mice. CCT196969 inhibits ERK and SRC and induce tumor regression in a PDX from the resistant tumor without causing body weight loss in the mice[1].

IC 50

BRafV600E: 0.04 μM (IC50); Braf: 0.1 μM (IC50); CRAF: 0.01 μM (IC50); LCK: 0.02 μM (IC50); SRC: 0.03 μM (IC50)

CCT196969 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT196969 Suppliers

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1163719-56-9, CCT196969Related Search:

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide CCT245737 3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-

  • CCT196969
  • 1-(3-(tert-Butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyra
  • CCT196969; CCT-196969; CCT 196969
  • CS-2447
  • Urea, N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-
  • CCT 196969,Raf,CCT196969,CCT-196969,Inhibitor,inhibit,Raf kinases
  • CCT196969, 10 mM in DMSO
  • CCT196969 ，S7743
  • CCT196969 (CCT-196969
  • 1163719-56-9
  • C27H24FN7O3