ChemicalBook > CAS DataBase List > CCT245737

CCT245737

Product Name
CCT245737
CAS No.
1489389-18-5
Chemical Name
CCT245737
Synonyms
SRA737;SRA 737;CS-2519;CCT245737;SRA737(CCT245737);CCT-245737 (SRA-737;CCT-245737 (PNT-737);CCT245737, 10 mM in DMSO;CCT245737; CCT 245737; CCT-245737.;SRA-737;SRA737;SRA 737;CCT245737;CCT 245737
CBNumber
CB13139058
Molecular Formula
C16H16F3N7O
Formula Weight
379.34
MOL File
1489389-18-5.mol
More
Less

CCT245737 Property

Boiling point:
547.2±50.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:53.5(Max Conc. mg/mL);141.03(Max Conc. mM)
Ethanol:9.0(Max Conc. mg/mL);23.72(Max Conc. mM)
form 
A crystalline solid
pka
8.56±0.40(Predicted)
color 
White to yellow
InChI
InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1
InChIKey
YBYYWUUUGCNAHQ-LLVKDONJSA-N
SMILES
C1(C#N)=NC=C(NC2=NC=C(C(F)(F)F)C(NC[C@@H]3OCCNC3)=C2)N=C1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28775
Product name
CCT245737
Packaging
5mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
28775
Product name
CCT245737
Packaging
10mg
Price
$150
Updated
2024/03/01
TRC
Product number
C227970
Product name
CCT245737
Packaging
50mg
Price
$635
Updated
2021/12/16
ChemScene
Product number
CS-5863
Product name
CCT245737
Purity
99.35%
Packaging
100mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-5863
Product name
CCT245737
Purity
99.35%
Packaging
5mg
Price
$100
Updated
2021/12/16
More
Less

CCT245737 Chemical Properties,Usage,Production

Uses

CCT245737 is a CHK inhibitor.

in vivo

CCT245737 (150 mg/kg p.o.) inhibits tumor growth in combination with LY 188011 (100 mg/kg iv) in HT29 colon cancer xenografts. CCT245737 (300 mg/kg, p.o.) also inhibits the LY 188011 (60 mg/kg iv) induced pSer296 CHK1 autophosphorylation at 24 h in SW620 human colon cancer xenografts[1]. CCT245737 (150 mg/kg, p.o) alone significantly inhibits tumor growth in an Eμ-Myc mouse model of human B-cell lymphocytic leukemia[2].

IC 50

Chk1: 1.3 nM (IC50); Chk2: 2440 nM (IC50); ERK8: 130 nM (IC50); PKD1: 298 nM (IC50); RSK2: 361 nM (IC50); RSK1: 362 nM (IC50); FLT3: 582 nM (IC50); MARK3: 698 nM (IC50); NUAK1: 711 nM (IC50); CLK2: 1370 nM (IC50); BRSK1: 1660 nM (IC50); AMPK: 2970 nM (IC50); PHK: 3470 nM (IC50); CDK2/CyclA: 3850 nM (IC50); CDK1/CyclB: 9030 nM (IC50)

CCT245737 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CCT245737 Suppliers

China 85 India 1 United States 8 USA 1 Global 95
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.
Tel
13771642864
Fax
1078336263
Email
snhuyu_2008@126.com
Country
China
ProdList
1165
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Hui Chem Co., Ltd.
Tel
021-34799779 18918539052
Fax
021-61916468
Email
1879902218@qq.com
Country
China
ProdList
77
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55

1489389-18-5, CCT245737Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 CC-92480 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- CC-885 CCF-642 CCT196969 N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide 3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-

  • CCT245737
  • CCT-245737 (SRA-737
  • SRA 737
  • SRA737
  • CS-2519
  • SRA-737;SRA737;SRA 737;CCT245737;CCT 245737
  • CCT245737; CCT 245737; CCT-245737.
  • 2-Pyrazinecarbonitrile, 5-[[4-[[(2R)-2-morpholinylmethyl]amino]-5-(trifluoromethyl)-2-pyridinyl]amino]-
  • (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile
  • CCT245737,Inhibitor,CCT 245737,inhibit,Checkpoint Kinase (Chk),CCT-245737
  • SRA737(CCT245737)
  • CCT-245737 (PNT-737)
  • CCT245737, 10 mM in DMSO
  • 1489389-18-5