ChemicalBook > CAS DataBase List > CCT245737

CCT245737

Product Name
CCT245737
CAS No.
1489389-18-5
Chemical Name
CCT245737
Synonyms
SRA737;SRA 737;CS-2519;CCT245737;SRA737(CCT245737);CCT-245737 (SRA-737;CCT-245737 (PNT-737);CCT245737, 10 mM in DMSO;CCT245737; CCT 245737; CCT-245737.;SRA-737;SRA737;SRA 737;CCT245737;CCT 245737
CBNumber
CB13139058
Molecular Formula
C16H16F3N7O
Formula Weight
379.34
MOL File
1489389-18-5.mol
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CCT245737 Property

Boiling point:
547.2±50.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:53.5(Max Conc. mg/mL);141.03(Max Conc. mM)
Ethanol:9.0(Max Conc. mg/mL);23.72(Max Conc. mM)
form 
A crystalline solid
pka
8.56±0.40(Predicted)
color 
White to yellow
InChI
InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1
InChIKey
YBYYWUUUGCNAHQ-LLVKDONJSA-N
SMILES
C1(C#N)=NC=C(NC2=NC=C(C(F)(F)F)C(NC[C@@H]3OCCNC3)=C2)N=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28775
Product name
CCT245737
Packaging
5mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
28775
Product name
CCT245737
Packaging
10mg
Price
$150
Updated
2024/03/01
TRC
Product number
C227970
Product name
CCT245737
Packaging
50mg
Price
$635
Updated
2021/12/16
ChemScene
Product number
CS-5863
Product name
CCT245737
Purity
99.35%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-5863
Product name
CCT245737
Purity
99.35%
Packaging
10mg
Price
$150
Updated
2021/12/16
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CCT245737 Chemical Properties,Usage,Production

Uses

CCT245737 is a CHK inhibitor.

in vivo

CCT245737 (150 mg/kg p.o.) inhibits tumor growth in combination with LY 188011 (100 mg/kg iv) in HT29 colon cancer xenografts. CCT245737 (300 mg/kg, p.o.) also inhibits the LY 188011 (60 mg/kg iv) induced pSer296 CHK1 autophosphorylation at 24 h in SW620 human colon cancer xenografts[1]. CCT245737 (150 mg/kg, p.o) alone significantly inhibits tumor growth in an Eμ-Myc mouse model of human B-cell lymphocytic leukemia[2].

IC 50

Chk1: 1.3 nM (IC50); Chk2: 2440 nM (IC50); ERK8: 130 nM (IC50); PKD1: 298 nM (IC50); RSK2: 361 nM (IC50); RSK1: 362 nM (IC50); FLT3: 582 nM (IC50); MARK3: 698 nM (IC50); NUAK1: 711 nM (IC50); CLK2: 1370 nM (IC50); BRSK1: 1660 nM (IC50); AMPK: 2970 nM (IC50); PHK: 3470 nM (IC50); CDK2/CyclA: 3850 nM (IC50); CDK1/CyclB: 9030 nM (IC50)

CCT245737 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT245737 Suppliers

China 85 India 1 United States 8 USA 1 Global 95
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.
Tel
13771642864
Fax
1078336263
Email
snhuyu_2008@126.com
Country
China
ProdList
1165
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Hui Chem Co., Ltd.
Tel
021-34799779 18918539052
Fax
021-61916468
Email
1879902218@qq.com
Country
China
ProdList
77
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55

1489389-18-5, CCT245737Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 CC-92480 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- CC-885 CCF-642 CCT196969 N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide 3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-

  • CCT245737
  • CCT-245737 (SRA-737
  • SRA 737
  • SRA737
  • CS-2519
  • SRA-737;SRA737;SRA 737;CCT245737;CCT 245737
  • CCT245737; CCT 245737; CCT-245737.
  • 2-Pyrazinecarbonitrile, 5-[[4-[[(2R)-2-morpholinylmethyl]amino]-5-(trifluoromethyl)-2-pyridinyl]amino]-
  • (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile
  • CCT245737,Inhibitor,CCT 245737,inhibit,Checkpoint Kinase (Chk),CCT-245737
  • SRA737(CCT245737)
  • CCT-245737 (PNT-737)
  • CCT245737, 10 mM in DMSO
  • 1489389-18-5