CC-92480

Product Name: CC-92480
CAS No.: 2259648-80-9
Chemical Name: CC-92480
Synonyms: Mezigdomide;Benzonitrile, 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-;CC92489;CC-92480;RSYY（Avanafil)-4;Avanafil Impurity 80;Mezigdomide(CC-92480);CC-92480 ( Mezigdomide );(S)-4-[4-[4-[[[2-(2,6-Dioxo-3-piperidyl)-1-oxo-4-isoindolinyl]oxy]methyl]benzyl]-1-piperazinyl]-3-fluorobenzonitrile;(S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile
CBNumber: CB45821189
Molecular Formula: C32H30FN5O4
Formula Weight: 567.61
MOL File: 2259648-80-9.mol

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CC-92480 Property

Boiling point:: 833.0±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 10.70±0.40(Predicted)
color: White to off-white
InChIKey: YTINZZFBHWSAGL-NDEPHWFRSA-N
SMILES: C(#N)C1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@H]4CCC(=O)NC4=O)C5=O)C=C3)CC2)C(F)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0105182
Product name: CC-92480
Purity: 98.02%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0105182
Product name: CC-92480
Purity: 98.02%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0105182
Product name: CC-92480
Purity: 98.02%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0105182
Product name: CC-92480
Purity: 98.02%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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CC-92480 Chemical Properties,Usage,Production

Uses

Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity[1].

References

[1] Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31. DOI:10.1097/PPO.0000000000000354

CC-92480 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC-92480 Suppliers

China 68 United States 4 Global 72

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2259648-80-9, CC-92480Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- CC-885 CCT245737 CCF-642 CC-90001 CC-90009 CC-223 CC-90011

CC-92480

Benzonitrile, 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-

CC92489

Mezigdomide

(S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile

RSYY（Avanafil)-4

CC 92480,Molecular Glues,Ubiquitin ligase,Ubiquitin activating enzyme,E1/E2/E3 Enzyme,Apoptosis,inhibit,E1 activating enzyme,Mezigdomide,E2 conjugating enzyme,Inhibitor,Ubiquitin conjugating enzyme,CC92480,E3 ligating enzyme

Avanafil Impurity 80

(S)-4-[4-[4-[[[2-(2,6-Dioxo-3-piperidyl)-1-oxo-4-isoindolinyl]oxy]methyl]benzyl]-1-piperazinyl]-3-fluorobenzonitrile

CC-92480 ( Mezigdomide )

Mezigdomide(CC-92480)

4-[4-[[4-[[[2-[(3S)-2,6-Dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluorobenzonitrile

2259648-80-9

C32H30FN5O4