ChemicalBook > CAS DataBase List > CC-90011

CC-90011

Product Name
CC-90011
CAS No.
2097523-60-7
Chemical Name
CC-90011
Synonyms
CC-90011;CC-90011 besylate;CC-90011 besylicacid;LSD1-IN-7 benzenesulfote;CC-90011 benzenesulfonate;LSD1-IN-7 benzenesulfonate;Pulrodemstat benzenesulfonate;Pulrodemstat (CC90011) besylate;Pulrodemstat benzenesulfonate, 10 mM in DMSO;CC-90011; CC90011; CC 90011; CC-90011 BESYLATE;
CBNumber
CB55544449
Molecular Formula
C30H29F2N5O5S
Formula Weight
609.65
MOL File
2097523-60-7.mol
More
Less

CC-90011 Property

solubility 
DMSO:62.5(Max Conc. mg/mL);102.52(Max Conc. mM)
form 
Solid
color 
Off-white to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0113540
Product name
CC-90011benzenesulfonate
Purity
99.39%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0113540
Product name
CC-90011benzenesulfonate
Purity
99.39%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0113540
Product name
CC-90011benzenesulfonate
Purity
99.39%
Packaging
50mg
Price
$850
Updated
2021/12/16
ChemScene
Product number
CS-0113540
Product name
CC-90011benzenesulfonate
Purity
99.39%
Packaging
100mg
Price
$1450
Updated
2021/12/16
DC Chemicals
Product number
DC26140
Product name
CC-90011besylate
Purity
>98%
Packaging
1g
Price
$2400
Updated
2021/12/16
More
Less

CC-90011 Chemical Properties,Usage,Production

Uses

CC-90011 benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. CC-90011 benzenesulfonate is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. CC-90011 benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].

in vivo

CC-90011 (5 mg/kg; oral administration; daily; for 30 days) treatment inhibits tumor growth in patient-derived xenograft SCLC models[1].
CC-90011 (once a day; for 4 days) treatment results in robust downregulation of GRP mRNA levels at 2.5 mg/kg and maximum suppression of GRP at 5 mg/kg in a SCLC human tumor xenograft (H1417) mice[1].
After i.v. administration, CC-90011 (Compound 11; 5 mg/kg) has systemic clearance of 32.4 mL/min/kg, elimination half-life of 2 h, and a high volume of distribution of 7.5 L/kg. CC-90011 (Compound 11; 5 mg/kg) is readily absorbed after oral administration with an AUC0-24h of 1.8 μM·h, C/sub>max of 0.36 μM, and oral bioavailability of 32%[1].

Animal Model:BALB/c nude mice bearing small cell lung carcinoma (SCLC)[1]
Dosage:5 mg/kg
Administration:Oral administration; daily; for 30 days
Result:Showed a tumor growth inhibition (TGI) of 78% at 5 mg/kg with no body weight loss.

IC 50

KDM1/LSD1

References

[1] Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529. DOI:10.1021/acs.jmedchem.0c00978

CC-90011 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CC-90011 Suppliers

China 53 India 1 United States 5 Global 59
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2989
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
0530-+86-530-529 6766，+86-15666160102 15666160102
Fax
0530-529 6766
Email
info@chuangli-chem.com
Country
China
ProdList
836
Advantage
55
Fujian boshi pharmaceutical technology co. LTD
Tel
0595-22008920; 18120708884
Email
393612455@qq.com
Country
China
ProdList
255
Advantage
58

2097523-60-7, CC-90011Related Search:

CC-90001 CC-90009 CC-223 CC-92480

  • CC-90011 besylate
  • CC-90011; CC90011; CC 90011; CC-90011 BESYLATE;
  • CC-90011
  • LSD1-IN-7 benzenesulfonate
  • LSD1-IN-7 benzenesulfote
  • CC-90011 besylicacid
  • CC-90011 benzenesulfonate
  • Pulrodemstat benzenesulfonate
  • Pulrodemstat (CC90011) besylate
  • 4-(2-(4-Aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-2-fluorobenzonitrile benzenesulfonate
  • LSD1,Pulrodemstat,oral,SCLC,reversible,CC-90011,cell,CC90011,anticancer,Histone Demethylase,differentiation,inhibit,Inhibitor,AML,CC 90011,Pulrodemstat benzenesulfonate
  • Pulrodemstat benzenesulfonate, 10 mM in DMSO
  • 2097523-60-7