CC-90009

Product Name: CC-90009
CAS No.: 1860875-51-9
Chemical Name: CC-90009
Synonyms: CC-90009;Eragidomide;CC-90009 ，S9832;Cereblon modulator 1;Eragidomide(CC-90009);Eragidomide, 10 mM in DMSO;Cereblon modulator 1（CC-99）;CC-90009; CC 90009; CC90009;;2-(4-Chlorophenyl)-N-[[2-(2,6-dioxo-3-piperidyl)-1-oxoisoindolin-5-yl]methyl]-2,2-difluoroacetamide;2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
CBNumber: CB15833721
Molecular Formula: C22H18ClF2N3O4
Formula Weight: 461.85
MOL File: 1860875-51-9.mol

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CC-90009 Property

Boiling point:: 770.1±60.0 °C(Predicted)
Density: 1.466±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (541.30 mM)
form: A crystalline solid
pka: 10.66±0.40(Predicted)
color: Off-white to light yellow
InChIKey: PWBHUSLMHZLGRN-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(CNC(=O)C(C3C=CC(Cl)=CC=3)(F)F)C=C2CN1C1CCC(=O)NC1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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CC-90009 Chemical Properties,Usage,Production

Uses

Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation[1][2].

IC 50

Cereblon

References

[1] Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677. DOI:10.1182/blood.2020008676
[2] Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 Feb 25;64(4):1835-1843. DOI:10.1021/acs.jmedchem.0c01489

CC-90009 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC-90009 Suppliers

China 78 United States 5 Global 83

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1860875-51-9, CC-90009Related Search:

CC-90001 CC-223 CC-92480 CC-90011

CC-90009

CC-90009; CC 90009; CC90009;

Cereblon modulator 1

Benzeneacetamide, 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-

Cereblon modulator 1（CC-99）

Eragidomide

Eragidomide(CC-90009)

proteasome-mediated,CRBN,degradation,Eragidomide,CC-90009,Molecular Glues,E3 ligase-recruiting Moiety,IKZF3,IRF4,IKZF1,c-myc,Inhibitor,anti-cancer,Ligands for E3 Ligase,inhibit,CC 90009,Apoptosis,CC90009,T-lymphocytes

2-(4-Chlorophenyl)-N-[[2-(2,6-dioxo-3-piperidyl)-1-oxoisoindolin-5-yl]methyl]-2,2-difluoroacetamide

2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide

2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Eragidomide, 10 mM in DMSO

CC-90009 ，S9832

1860875-51-9

C22H18ClF2N3O4

APIS