CC-90001

Product Name: CC-90001
CAS No.: 1403859-14-2
Chemical Name: CC-90001
Synonyms: CC90001;CC-90001;CAS:1403859-14-2;CC90001 free base;CC-90001, 10 mM in DMSO;2-(tert-Butylamino)-4-(((1R,3R,4R)-3-hydroxy-4-methylcyclohexyl)amino)pyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, 2-[(1,1-dimethylethyl)amino]-4-[[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino]-;CC90001,kinase,IPF,JNK,c-Jun,idiopathic,JNK1,Inhibitor,N-terminal,inhibit,CC-90001,CC 90001,fibrosis,pulmonary
CBNumber: CB15494038
Molecular Formula: C16H27N5O2
Formula Weight: 321.42
MOL File: 1403859-14-2.mol

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CC-90001 Property

Boiling point:: 549.5±60.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (777.80 mM; Need ultrasonic)
pka: 14.17±0.50(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 10mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 25mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 50mg
Price: $2550
Updated: 2021/12/16

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 100mg
Price: $3800
Updated: 2021/12/16

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CC-90001 Chemical Properties,Usage,Production

Uses

CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis[1][2].

in vivo

CC-90001 (3 mg/kg b.i.d.) reduces the development of fibrosis, as evidenced by a 48% reduction in collagen and a 53% reduction in α-smooth muscle actin (α-SMA) in a steatohepatitis model^[1].
CC-90001 decreases multiple measures of lung collagen and reduces disease induced increases in α-SMA to nearly baseline levels in a house dust mite model of lung fibrosis^[1].

IC 50

JNK1; JNK2

References

[1] Bennett B, et, al. CC-90001, a Second Generation Jun N-Terminal Kinase (JNK) Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2017; 195:A5409.
[2] Kolb M, et, al. Therapeutic targets in idiopathic pulmonary fibrosis. Respir Med. 2017 Oct;131:49-57. DOI:10.1016/j.rmed.2017.07.062

CC-90001 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC-90001 Suppliers

China 47 United States 5 Global 52

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
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BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
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ShangHai Biochempartner Co.,Ltd

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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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Fujian boshi pharmaceutical technology co. LTD

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Email: 393612455@qq.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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1403859-14-2, CC-90001Related Search:

CC-90009 Onatasertib (CC-223) CC-92480 CC-90011

CC90001

CC-90001

CC90001 free base

CC90001,kinase,IPF,JNK,c-Jun,idiopathic,JNK1,Inhibitor,N-terminal,inhibit,CC-90001,CC 90001,fibrosis,pulmonary

5-Pyrimidinecarboxamide, 2-[(1,1-dimethylethyl)amino]-4-[[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino]-

2-(tert-Butylamino)-4-(((1R,3R,4R)-3-hydroxy-4-methylcyclohexyl)amino)pyrimidine-5-carboxamide

CC-90001, 10 mM in DMSO

CAS:1403859-14-2

1403859-14-2