ChemicalBook > CAS DataBase List > CC-90001

CC-90001

Product Name: CC-90001
CAS No.: 1403859-14-2
Chemical Name: CC-90001
Synonyms: CC90001;CC-90001;CAS:1403859-14-2;CC90001 free base;CC-90001, 10 mM in DMSO;2-(tert-Butylamino)-4-(((1R,3R,4R)-3-hydroxy-4-methylcyclohexyl)amino)pyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, 2-[(1,1-dimethylethyl)amino]-4-[[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino]-;CC90001,kinase,IPF,JNK,c-Jun,idiopathic,JNK1,Inhibitor,N-terminal,inhibit,CC-90001,CC 90001,fibrosis,pulmonary
CBNumber: CB15494038
Molecular Formula: C16H27N5O2
Formula Weight: 321.42
MOL File: 1403859-14-2.mol

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CC-90001 Property

Boiling point:: 549.5±60.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (777.80 mM; Need ultrasonic)
pka: 14.17±0.50(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 10mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 25mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 50mg
Price: $2550
Updated: 2021/12/16

ChemScene

Product number: CS-0147723
Product name: CC-90001
Purity: 99.67%
Packaging: 100mg
Price: $3800
Updated: 2021/12/16

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CC-90001 Chemical Properties,Usage,Production

Uses

CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis[1][2].

in vivo

CC-90001 (3 mg/kg b.i.d.) reduces the development of fibrosis, as evidenced by a 48% reduction in collagen and a 53% reduction in α-smooth muscle actin (α-SMA) in a steatohepatitis model^[1].
CC-90001 decreases multiple measures of lung collagen and reduces disease induced increases in α-SMA to nearly baseline levels in a house dust mite model of lung fibrosis^[1].

IC 50

JNK1; JNK2

References

[1] Bennett B, et, al. CC-90001, a Second Generation Jun N-Terminal Kinase (JNK) Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2017; 195:A5409.
[2] Kolb M, et, al. Therapeutic targets in idiopathic pulmonary fibrosis. Respir Med. 2017 Oct;131:49-57. DOI:10.1016/j.rmed.2017.07.062

CC-90001 Preparation Products And Raw materials

Raw materials

Preparation Products

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1403859-14-2, CC-90001Related Search:

CC-90009 CC-223 CC-92480 CC-90011

CC90001

CC-90001

CC90001 free base

CC90001,kinase,IPF,JNK,c-Jun,idiopathic,JNK1,Inhibitor,N-terminal,inhibit,CC-90001,CC 90001,fibrosis,pulmonary

5-Pyrimidinecarboxamide, 2-[(1,1-dimethylethyl)amino]-4-[[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino]-

2-(tert-Butylamino)-4-(((1R,3R,4R)-3-hydroxy-4-methylcyclohexyl)amino)pyrimidine-5-carboxamide

CC-90001, 10 mM in DMSO

CAS:1403859-14-2

1403859-14-2