ChemicalBook > CAS DataBase List > CC-90011

CC-90011

Product Name: CC-90011
CAS No.: 2097523-60-7
Chemical Name: CC-90011
Synonyms: CC-90011;CC-90011 besylate;CC-90011 besylicacid;LSD1-IN-7 benzenesulfote;CC-90011 benzenesulfonate;LSD1-IN-7 benzenesulfonate;Pulrodemstat benzenesulfonate;Pulrodemstat (CC90011) besylate;Pulrodemstat benzenesulfonate, 10 mM in DMSO;CC-90011; CC90011; CC 90011; CC-90011 BESYLATE;
CBNumber: CB55544449
Molecular Formula: C30H29F2N5O5S
Formula Weight: 609.65
MOL File: 2097523-60-7.mol

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CC-90011 Property

solubility: DMSO:62.5(Max Conc. mg/mL);102.52(Max Conc. mM)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0113540
Product name: CC-90011benzenesulfonate
Purity: 99.39%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0113540
Product name: CC-90011benzenesulfonate
Purity: 99.39%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0113540
Product name: CC-90011benzenesulfonate
Purity: 99.39%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0113540
Product name: CC-90011benzenesulfonate
Purity: 99.39%
Packaging: 100mg
Price: $1450
Updated: 2021/12/16

DC Chemicals

Product number: DC26140
Product name: CC-90011besylate
Purity: >98%
Packaging: 1g
Price: $2400
Updated: 2021/12/16

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CC-90011 Chemical Properties,Usage,Production

Uses

CC-90011 benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. CC-90011 benzenesulfonate is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. CC-90011 benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].

in vivo

CC-90011 (5 mg/kg; oral administration; daily; for 30 days) treatment inhibits tumor growth in patient-derived xenograft SCLC models^[1].
CC-90011 (once a day; for 4 days) treatment results in robust downregulation of GRP mRNA levels at 2.5 mg/kg and maximum suppression of GRP at 5 mg/kg in a SCLC human tumor xenograft (H1417) mice^[1].
After i.v. administration, CC-90011 (Compound 11; 5 mg/kg) has systemic clearance of 32.4 mL/min/kg, elimination half-life of 2 h, and a high volume of distribution of 7.5 L/kg. CC-90011 (Compound 11; 5 mg/kg) is readily absorbed after oral administration with an AUC_0-24h of 1.8 μM·h, C/sub>max of 0.36 μM, and oral bioavailability of 32%^[1].

Animal Model:	BALB/c nude mice bearing small cell lung carcinoma (SCLC)^[1]
Dosage:	5 mg/kg
Administration:	Oral administration; daily; for 30 days
Result:	Showed a tumor growth inhibition (TGI) of 78% at 5 mg/kg with no body weight loss.

IC 50

KDM1/LSD1

References

[1] Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529. DOI:10.1021/acs.jmedchem.0c00978

CC-90011 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC-90011 Suppliers

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2097523-60-7, CC-90011Related Search:

CC-90001 CC-90009 CC-223 CC-92480

CC-90011 besylate

CC-90011; CC90011; CC 90011; CC-90011 BESYLATE;

CC-90011

LSD1-IN-7 benzenesulfonate

LSD1-IN-7 benzenesulfote

CC-90011 besylicacid

CC-90011 benzenesulfonate

Pulrodemstat benzenesulfonate

Pulrodemstat (CC90011) besylate

4-(2-(4-Aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-2-fluorobenzonitrile benzenesulfonate

LSD1,Pulrodemstat,oral,SCLC,reversible,CC-90011,cell,CC90011,anticancer,Histone Demethylase,differentiation,inhibit,Inhibitor,AML,CC 90011,Pulrodemstat benzenesulfonate

Pulrodemstat benzenesulfonate, 10 mM in DMSO

2097523-60-7