CCF-642

Product Name: CCF-642
CAS No.: 346640-08-2
Chemical Name: CCF-642
Synonyms: CCF-642;AC1LYELL;CCF 642, ≥98%;CCF 642;CCF-642;CCF642 >=98% (HPLC);CCF 642;CCF-642;AC1LYELL;3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-;3-(4-Methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one;calcium,Inhibitor,PDI,CCF642,apoptosis,isomerases,disulfide,myeloma,CCF-642,protein,multiple,release,stress,inhibit,anti-multiple,CCF 642
CBNumber: CB13133223
Molecular Formula: C15H10N2O4S3
Formula Weight: 378.45
MOL File: 346640-08-2.mol

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CCF-642 Property

Boiling point:: 567.3±60.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:14.4(Max Conc. mg/mL);38.05(Max Conc. mM)
form: powder
pka: -0.70±0.20(Predicted)
color: yellow to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1827
Product name: CCF642
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1827
Product name: CCF642
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $464
Updated: 2024/03/01

Cayman Chemical

Product number: 27054
Product name: CCF-642
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 27054
Product name: CCF-642
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 27054
Product name: CCF-642
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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CCF-642 Chemical Properties,Usage,Production

Uses

CCF642 has been used as a protein disulfide isomerase (PDI) inhibitor to study its ability to reduce the expression of endoplasmic reticulum (ER) stress markers and neuroinflammation in the hippocampus of experimental autoimmune encephalomyelitis (EAE) mice.

Biochem/physiol Actions

CCF642 is a cell-permeable protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action that most likely involves PDI active-site CGHCK motifs instead of cysteine known to be targeted by PACMA 31. CCF642 displays anti-multiple myeloma (MM) activity both in cultures in vitro (IC50 <1 μM against murine 5TGM1 and nine human MM lines) and in mice in vivo (10 mg/kg, 3X i.p. per wk) without apparent adverse effects to the animals or being cytotoxic to normal bone marrow (NLBM) cells even at concentrations as high as 6.75 μM. Consistent with PDI′s role in ER protein folding process, CCF642 treatment causes acute ER stress accompanied by apoptosis-inducing calcium release in MM cells.

CCF-642 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCF-642 Suppliers

China 59 India 1 United Kingdom 1 United States 6 USA 1 Global 68

Shanghai Boyle Chemical Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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EnliPharma Technology Co., Ltd

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Sigma-Aldrich

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Zhengzhou Saifun Biotechnology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Rechem science Co., Ltd.

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Beijing Solarbio Science & Tecnology Co., Ltd.

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Medi-tech Bioscientific Co., Ltd.

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346640-08-2, CCF-642Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 CC-92480 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- CC-885 CCT245737 4-Methoxy-3-nitrobenzoic acid

CCF-642

3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone

CCF 642;CCF-642

AC1LYELL

CCF 642;CCF-642;AC1LYELL

4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-

CCF642 >=98% (HPLC)

CCF 642, ≥98%

3-(4-Methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one

calcium,Inhibitor,PDI,CCF642,apoptosis,isomerases,disulfide,myeloma,CCF-642,protein,multiple,release,stress,inhibit,anti-multiple,CCF 642

346640-08-2